| Objective:Atherosclerotic cerebral infarction is a common type of cerebral infarction,which is a chronic inflammatory disease characterized by arterial lipid deposition and fibrinogen accumulation.At present,anti thrombotic and lipid lowering are the main treatment strategies.Literature research has found that Seabuckthorn 5 Flavored Powder may have the effects of promoting blood circulation and resolving stasis,protecting blood vessels,nourishing and strengthening the body,and regulating the circulation of qi and blood.This study was to observe the effect of the intervention of seabuckthorn 5 powder combined with western medicine(aspirin enteric coated tablets,atorvastatin calcium tablets)on the level of blood lipids(total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C))in atherosclerotic cerebral infarction,and provide clinical data for Mongolian medicine to intervene in atherosclerotic cerebral infarction.Method:95 patients with atherosclerotic cerebral infarction(Sarcoma)and dyslipidemia who were treated in the Affiliated Hospital of Inner Mongolia Minzu University from December2021 to February 2023 were randomly divided into an observation group of 48 cases and a control group of 47 cases.The observation group patients were treated with 20 mg of atorvastatin calcium tablets and 100 mg of aspirin enteric coated tablets plus Seabuckthorn 5 powder,3g in the morning and evening,respectively.The control group patients were treated with 20 mg of atorvastatin calcium tablets and 100 mg of aspirin enteric coated tablets.Both groups of patients received continuous treatment for 4 weeks.After 4 weeks,the control group continued to take20 mg of atorvastatin calcium tablets and 100 mg of aspirin enteric coated tablets orally,while the observation group stopped taking Seabuckthorn 5 Powder and continued to take 20 mg of atorvastatin calcium tablets and 100 mg of aspirin enteric coated tablets orally.Analyze the changes in blood lipid levels(TC,TG,LDL-C,HDL-C)before treatment,4 weeks of treatment,and 12 weeks of follow-up,as well as the changes in electrocardiogram,blood routine,liver and kidney function,coagulation function,and ion levels.Use SPSS 27.0 software for statistical analysis to draw conclusions.Result:1.After 4 weeks of treatment,the observation group showed a significant improvement in blood lipid levels,especially in total cholesterol(TC)and low-density lipoprotein(LDL-C),with significant statistical significance(P<0.01).2.After 4 weeks of treatment,the control group showed a significant improvement in blood lipid levels,with a significant difference in total cholesterol(TC)(P<0.01)and a significant decrease in low-density lipoprotein(LDL-C)levels(P<0.05).3.After 4 weeks of treatment,the blood lipid levels of the two groups were compared at the same time,and the levels of low-density lipoprotein(LDL-C)and total cholesterol(TC)were statistically significant(P<0.05).4.Follow up for 12 weeks to observe the levels of blood lipids in both groups.Both groups showed improvement in blood lipids,with a significant effect on total cholesterol(TC)(P<0.05)and a statistically significant decrease in low-density lipoprotein(LDL-C)(P<0.01).The comparison of blood lipid levels between the two groups during the same period showed statistical significance(P<0.05)for total cholesterol(TC)levels.5.By observing the electrocardiogram,blood routine,liver and kidney function,coagulation,ion and other safety tests of patients in the observation group and control group before treatment,4 weeks of treatment,and 12 weeks of follow-up,both groups showed elevated ALT levels.However,within the normal ALT range of our hospital,there were no other significant abnormal changes or toxic side effects.Conclusion:1.Mongolian medicine Hippophae rhamnoides-5 powder has obvious improvement effect on blood lipid level of atherosclerotic cerebral infarction,especially on total cholesterol(TC)and low-density lipoprotein(LDL-C).2.The Mongolian medicine Hippophae rhamnoides 5 has no side effects on patients with atherosclerotic cerebral infarction,and should be popularized in the recovery period and secondary prevention of patients with atherosclerotic cerebral infarction. |
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