To Explore The Timing Of Intervention In Local Retinal Photocoagulation After Conventional Anti-VEGF Therapy With BRVO

Objective: To explore the timing of intervention in local retinal photocoagulation after conventional anti-VEGF therapy with BRVO.Methods: A total of 65 BRVO patients admitted to the Inner Mongolia Forestry General Hospital from January 2020 to December 2022,34 eyes,31 eyes and 31 eyes in the group with neovascular vessels were collected.The foveal retinal thickness(central retinal thickness,CRT)> 250μm was used as an indication for intrabulbar injection of ranizμmab.Patients with no perfusion area(area 5DD)and neovascularization received local retinal laser treatment in the lesion area one week after anti-VE GF treatment,with a mean follow-up time of 14.7 weeks in the no-perfusion area group and 13.8 weeks in the neovascularization group.This study was conducted with the approval of the Ethics Committee of the Inner Mongolia Forestry General Hospital,in accordance with the tenets of the Declaration of Helsinki.All patients had complete medical records,including patient name,sex,age,past medical history,and signed informed consent for each injection,all were examined for ordinary remote vision,non-contact intraocular pressure measurement,fundus photography,Heidelberg optical coherence tomography OCT(spectral domain OCT,SD-OCT or fourier domain OCT,FD-OCT)instrμment,and all were followed up.This study was mainly based on OCT and FFA examination characteristics to find patients with ME secondary to BRVO,no-perfusion area and new Vas ES,and compared the changes of CRT and visual acuity after the anti-VE GF combined with local retinal laser treatment.Statistical analysis was performed using SPSS 25.0(SPSS Inc.,Chicago,USA)software.Measurement data were described statistically by((?)±SD),one-sampleKolmogorov-Smirnov test for normality test,analysis of variance,and LSD method for pairwise comparison when variance analysis was statistically significant.Results: BCVA and CRT in the non-perfusion group and neovascular group,adverse events were significantly better than neovascular group(10 cases category 3)and no-perfusion group(2 cases category 1)had adverse events,and the probability of vitreous accμmulation in the neovascular group was statistically significant(P <0.05);BCVA and CRT and neovascular group at 1 week and 3 months after combined therapy.The differences in age,sex,and intraocular pressure between the nonperfusion zone and neovascular groups were not obvious,and none of the above indicators were statistically significant(P> 0.05).There was no significant difference in the retinal hemorrhage absorption rate between the two groups(P> 0.05).Conclusion: After BRVO patients developed retinal nonperfusion areas and / or received anti-VE GF therapy combined with retinal grid-like laser treatment after retinal neovascularization,both patient-BCVA and CRT improved.After the combination therapy,the early improvement in visual acuity was more pronounced in the no-perfusion zone group.Early combined intervention in patients with no perfusion zone(S 5DD)can reduce the poor prognosis.