Correlation Analysis Of Early Abdominal Oxygen Saturation In Preterm Infants With Feed Intolerance

Objective:To investigate the correlation between tissue oxygen saturation（StO₂）and feeding intolerance（FI）in early postnatal infants,analyze the factors affectingabdominal oxygenation in preterm infants,and establish the normal reference value of abdominal StO₂ in the first week of life in preterm infants.It provides a reference for the assessment of FI in preterm infants or for the early differential diagnosis of necrotizing enterocolitis（NEC）.Methods:NIRS was used to continuously monitor the abdominal StO₂ of preterm infants at about 18:00 every day for about 15-30 minutes for about 15-30 minutes after birth,collect perinatal data of the mother and relevant clinical data of the child,and divide it into case group and control group for relevant statistical analysis based on whether FI appeared at 28 days after birth or at discharge.Results:A total of 20 patients were collected with abdominal StO₂ one week after birth,including 7 cases in the case group（one of these cases progressed to NEC）and 13 cases in the control group.The abdominal StO₂ of the children in the case group was lower than that of the control group within one week after birth（P=0.019）,which was not related to the gender,gestational age,weight,mechanical ventilation,etc.of the children.The proportion of mothers with perinatal premature rupture of membranes in the case group was higher than that in the control group（P=0.007）,and there was no significant difference between the mothers of the two groups with placenta previa,placental abruption and gestational diabetes.There was no significant difference in early laboratory indicators between the case group and the control group,early laboratory indicators were not correlated with FI or early NEC diagnosis,and abdominal StO₂ were correlated with laboratory indicators.The early abdominal StO₂ of the two groups was negatively correlated with the diagnosis of the disease（r=0.500,P=0.025）,that is the lower the abdominal StO₂,the greater the possibility of FI,and the borderline abdominal StO₂ was 53.9120%.There were no significant differences in gestational age,weight,and abdominal StO₂ between the different birth gestational ages,weight,and AGA and SGA groups.The correlation between daily abdominal StO₂ and daily feeding（ml/kg/d）within one week after birth showed that there was no significant correlation.The abdominal StO₂ of the children in each group was not statistically significant according to whether there was mechanical ventilation,PDA,and birth asphyxia,and the abdominal StO₂ of the infected group was lower than that of the control group（P=0.018）.Conclusion:In this study,the analysis of the early abdominal StO₂ of preterm infants in the early postnatal period was obtained through non-invasive real-time monitoring of NIRS bedside,and the early abdominal StO₂ was correlated with the occurrence of FI,and the decrease in early abdominal StO₂ indicated an increase in the probability of FI after birth,and the critical StO₂ was 53.9120%,and the lower the early abdominal StO₂,the greater the possibility of FI after birth.The normal abdominal StO₂ in the first week of life is about 60%.Factors affecting the abdominal StO₂ of preterm infants include:maternal premature rupture of membranes,and neonatal infection.It suggests that the occurrence of FI is closely related to infection.