| Objective:Based on the previous research results,this study observed the clinical efficacy and safety of the Quban Tuihong traditional Chinese medicine mask after optimization in prescription and preparation process in the treatment of postinflammatory erythema and hyperpigmentation of acne,and provided clinical basis for the development of a topical herbal mask for post-inflammatory erythema and hyperpigmentation of acne.Methods:In a randomized,open,synchronous control method,72 subjects who met the inclusion criteria were randomly divided into the experimental group and the control group,with 36 cases in each group.The experimental group used the Quban Tuihong traditional Chinese medicine mask once a day for 4 weeks,and the control group did not use mask,which was a blank control.During the trail,both groups were informed of normal skin care,receiving the same acne nursing education,and followed up at baseline,the second and fourth weekend when evaluated the skin lesion symptom scores and the visual analog scores(VAS)to evaluate the clinical effect of the Quban Tuihong traditional Chinese medicine mask from the perspective of researchers and subjects;In addition,the VISIA skin detector was used to collect images from the front,left and right sides of the subject’s face and detect the facial spots,red area and brown area values of the subjects.Then Adobe Photoshop 2022 software was used to analyze the RGB(red,green,blue)average value of selected target lesions and surrounding normal target skin in the images.The mean difference was calculated to objectively analyze and evaluate the clinical effect of the Quban Tuihong traditional Chinese medicine mask.All skin irritants and possible adverse reactions were recorded during the observation period.The SPSS26.0 statistical software was used for data analysis of the above observation indicators.Results:1.Skin lesion symptom scores:the scores of erythema symptom of the experimental group decreased gradually with the advance of treatment time,while erythema symptom scores of the control group were not affected by treatment time,and the scores of erythema symptom of the experimental group were lower than that of the control group at the 4th week(P<0.05);the scores of pigmentation symptom of the experimental group decreased gradually with the advance of treatment time,while pigmentation symptom scores of the control group were not affected by treatment time,and the score of pigmentation were lower than that of the control group at the 2nd and 4th week(P<0.05).2.VAS of subjects:the VAS of erythema of the experimental group decreased gradually with the advance of treatment time,while erythema VAS of the control group were not affected by treatment time,and the VAS of erythema of the experimental group were lower than those of control group at the 2nd and 4th week(P<0.05);the VAS of pigmentation of the experimental group decreased gradually with the advance of treatment time,while pigmentation VAS of the control group were not affected by treatment time,and the VAS of pigmentation of the experimental group were lower than those of control group at the 2nd and 4th week(P<0.05);the VAS of skin dullness of the experimental group decreased gradually with the advance of treatment time,while skin dullness VAS of the control group were not affected by treatment time,and the VAS of skin dullness of the experimental group were lower than those of control group at the 2nd and 4th week(P<0.05);the VAS of pore roughness of the experimental group decreased gradually with the advance of treatment time,while pore roughness VAS of the control group were not affected by treatment time,and the VAS of pore roughness of the experimental group were lower than those of control group at the 2nd and 4th week(P<0.05).3.The values of VISIA skin detector:the spot values of the experimental group and the control group were not affected by treatment time,and the spot values of experimental group were lower than baseline at the 4nd week(P>0.05),while at the 2nd week,the spot values of the control group were lower than that of the experimental group(P<0.05);the red area values of the experimental group and the control group were not affected by treatment time,and the red area values of experimental group were lower than baseline,in additon,the red area values of the experimental group were lower than that of the control group at the 4th week(P>0.05);the brown area values of the experimental group and the control group were not affected by treatment time,and the brown area values of both groups were lower than baseline,in addition,the brown area values of the experimental group were lower than that of the control group at the 4th week(P>0.05).4.The image RGB mean difference of target lesions and normal target skin:the erythema and pigmentation RGB mean difference of the experimental and the control group both decreased gradually with the progress of treatment time,but the erythema and pigmentation RGB mean difference of experimental group were lower than the control group at the 2nd and 4th week(P<0.05).5.Clinical efficacy:in terms of the improvement of erythema degree,the total effective rate increased gradually with the advance of treatment time,and the total effective rate of the experimental group was 85.29%at the 4th week,while the control group was 14.71%,which was significantly higher than the control group(P<0.001).In terms of the improvement of pigmentation degree,the 4-week total effective rate of the experimental group was 76.47%,while the control group was 11.76%,and the 4week total effective rate of pigmentation in the experimental group was significantly higher than the control group(P<0.001).6.Safety:during the observation period,3 cases of adverse reactions occurred in the experimental group,while there were 0 cases of adverse reactions in the control group.There was no statistical difference in the number of adverse reactions between the two groups(P>0.05).Conclusion:The Quban Tuihong traditional Chinese medicine mask is effective and safe in treating post-inflammatory erythema and hyperpigmentation of acne,and can significantly shrink the course of erythema and pigmentation,which is suitable for clinical application and promotion. |
PDF Full Text Request