The Medication Pattern Of Director Chao Guojun In The Treatment Of Retinalvein Obstructive Macular Edema Through Data Mining

Objective:Using the traditional Chinese medicine inheritance computing platform for data mining,summarize the medication patterns of Professor Chao Guojun in the treatment of retinal vein occlusion secondary macular edema(RVO-ME),explore its potential drug compatibility characteristics,summarize a set of universal ideas for traditional Chinese medicine treatment of RVO-ME,extract clinical experience and characteristic understanding,and inspire clinical prescription medication.Methods:Select the archived medical records diagnosed as RVO-ME from the inpatients in the Department 1 of Obstructive Ophthalmology,Affiliated Ophthalmology Hospital of the China Academy of Chinese Medical Sciences treated by professor Chao Guojun from January 2015 to December 2021,extract,sort out and summarize the data,screen out the fully qualified medical records,and create the RVO-ME personal information medical record database;Subsequently,the analysis function of the "Statistical Analysis Module" for the Four Qi,Five Flavors,Meridian tropism,and Efficacy of the Traditional Chinese Medicine Inheritance Computing Platform(V3.0),as well as the correlation and cluster analysis function of the "Formula Analysis Module",were used to deeply mine and interpret the original medical record data in the RVO-ME personal information medical record database.Results:1.Gender and age:A total of 245 medical records were collected this time,including 115 males(46.9%)and 130 females(53.1%);The youngest patient is 29 years old,the oldest patient is 84 years old,and the average patient age is 60.5 years old.The most common age range for onset is between 61 and 80 years old.2.Symptoms:According to the statistical results of syndromes,there are 28 cases of Qi stagnation and blood stasis type(1.4%),28 cases of Yin deficiency and fire hyperactivity type(11.4%),103 cases of phlegm stasis intertwined type(42.0%),14 cases of liver yang hyperactivity type(5.7%),36 cases of Qi deficiency and blood stasis type(14.7%),and 36 cases of liver kidney yin deficiency type(14.7%);3.Medication:There are a total of 245 formulas,involving 219 types of drugs.The cumulative frequency of use is 4551 times,and there are 24 drugs with a frequency of use exceeding 60,mainly promoting blood circulation and resolving blood stasis(23.11%).The frequency of drug use varies among different syndrome types:①Qi stagnation and blood stasis type:Chaihu(89.29%),Sanqi powder(89.29%),Angelica sinensis(82.14%),Chuanxiong(78.57%),and Raw Rehmannia glutinosa(75.00%);②Yin deficiency and fire hyperactivity type:Xiaoji(89.29%),Sanqi powder(82.14%),Raw Rehmannia glutinosa(78.57%),Danshen(71.43%);③Phlegm stasis mutual type:Sanqi powder(91.26%),Angelica sinensis(89.32%),Chuanxiong(87.38%),Raw Rehmannia glutinosa(82.52%)Honghua(80.58%),④Liver Yang hyperactivity type:Raw Atractylodes macrocephala(78.57%),Poria cocos(71.43%),Angelica sinensis(64.29%),Gouteng(57.14%),⑤Qi deficiency and blood stasis type:Angelica sinensis(97.22%),Chuanxiong(91.67%),Sanqi powder(88.89%),roasted Astragalus membranaceus(88.89%),raw Rehmannia glutinosa(86.11%),⑥Liver kidney yin deficiency type:Raw Rehmannia glutinosa(91.67%),Angelica sinensis(77.78%),Sanqi powder(77.78%),goji berry(72.22%);4.Association rule:Based on the screening requirement of "frequency≥ 122(half of the total number of medical records),probability of simultaneous occurrence≥99%",different drug combinations were obtained:14 groups;5.Cluster analysis:Cluster analysis is conducted on each syndrome type,sorted according to the degree of adhesion between drugs.Each syndrome type outputs six high-frequency clustering formulas,as follows:Qi stagnation and blood stasis type:①Honghua,Sanqi powder,Taoren,Danggui,Chuanxiong,Zelan,Chaihu,Leonurus,etc.Yin deficiency and excessive fire type:①Qumai,Poria cocos,White peony,Peony bark,Sanqi powder,etc.Phlegm stasis type:①Angelica sinensis,Ligusticum chuanxiong,safflower,peach kernel,Panax notoginseng powder,Achyranthes bidentata,corn whiskers,raw Rehmannia glutinosa,etc.Type of liver yang hyperactivity:①Huai Niu Xi,raw oysters,Poria cocos,raw atractylodes macrocephala,Sanqi powder,raw dragon bone,Huanglian,mulberry leaves,etc.Qi deficiency and blood stasis type:① Panax notoginseng powder,plantain seed,kudzu root,raw atractylodes macrocephala,raw rehmannia glutinosa,safflower,etc.Type of liver and kidney yin deficiency:① Duhuo,mulberry leaves,kudzu root,raw rehmannia,mulberry parasitic,Sanqi powder,roasted Huangqi,etc.Conclusions:1.Incidence:There is no significant gender difference in the incidence of macular edema secondary to retinal vein occlusion(RVO-ME)in patients,and the incidence is mainly concentrated in the elderly population;2.Classification of medication:①Liver soothing and Qi promoting drugs:Bupleurum chinense,Chuanxiong,Fructus aurantii,etc;② Activating blood circulation and resolving stasis:peach kernel,safflower,typhus,notoginseng powder,etc;③Nourishing Blood and Softening the Liver:raw herbs,white peony,angelica,mulberry seeds,etc;④Channels and collaterals:pueraria lobata,chuanxiong,panax notoginseng,white peony,cassia twig,etc;⑤Mingmu category:Prunella vulgaris,plantain seed,mulberry leaves,cassia seed,raspberry,ligustrum lucidum seed,etc.;⑥Experienced drugs:Hawthorn,Gentiana macrophylla,Pueraria lobata,Cinnamomum cassia,etc;⑦Dehydration and moisture absorption categories:Poria cocos,corn whiskers,loofah,Tianshan Snow Lotus,etc;⑧ Pinggan Qianyang category:Cassia obtusifolia,Uncaria,Tribulus terrestris,Leonurus heterophyllus,Morus parasiticus,Achyranthes bidentata,etc;⑨Nourishing liver and kidney:Chinese wolfberry fruit,Ligustrum lucidum seed,Tianshan Snow Lotus,Eclipta chinensis,Broussonetia papyrifera seed,Leonurus japonicus seed;According to association rules and clustering results,combined with clinical experience,the commonly used drug pairs for the treatment of RVO-ME were summarized as breviscapine and roasted astragalus,Prunella vulgaris and Fritillaria thunbergii.Screening representative core formulas:Qi stagnation and blood stasis type:Sanqi powder,pueraria lobata,white peony,angelica,Chuanxiong,raw materials,fried orange peel,and bupleurum chinense.Yin deficiency and fire hyperactivity type:peony bark,dry lotus root,salvia miltiorrhiza,artichoke,coix seed,tuckahoe,raw cypress leaves,raw typhus.Phlegm and blood stasis type:Panax notoginseng powder,Poria cocos,Angelica sinensis,salvia miltiorrhiza,red peony,safflower,Chuanxiong,raw material.Type of hyperactivity of liver yang:Uncaria,Poria cocos,Eucommia ulmoides,Leonurus heterophyllus,Maize whiskers,Scutellaria baicalensis,raw atractylodes macrocephala,mulberry parasitic.Type of Qi Deficiency and Blood Stasis:Safflower,Sanqi Powder,Roasted Astragalus,Peach Kernel,Angelica Sinensis,Cinnamomum Cinnamomi,Chuanxiong,Pueraria lobata.Liver and Kidney Yin Deficiency Type:Prunella vulgaris,Panax notoginseng powder,Eclipta chinensis,Ligustrum lucidum,Chinese wolfberry fruit,raw land,Snow Lotus from Tianshan Mountains,mulberry leaves;4.Diagnosis and treatment characteristics:① Reconciling yin and yang,applying both attack and tonic;②Smooth the internal organs,especially the qi and blood;③ A combination of Chinese and Western cultures,drawing on the strengths of others.