Clinical Study Of The Treatment Of Chronic Obstructive Pulmonary Disease Complicated With Anxiety States Using Shenling Xianxiong Decoction

Objectives: This research aims to observe the efficacy and safety of Shenling Xianxiong Decoction(Ginseng and Poria Chest Bind Decoction)in treating chronic obstructive pulmonary diseases(COPD)complicated with anxiety,thereby providing theoretical and clinically practical evidence for improving the living quality of patients with COPD complicated with anxiety.Method: A randomized controlled trial incorporating 66 patients suffering from COPD complicated with anxiety hosptialized in respiratory disease wards of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from December 2020 to December 2021 was conducted.Patents were allocated to treatment and control groups at a 1:1 ratio using a random number table,with 35 subjects and 2 dropouts in the treatment group and 35 subjects and 2 dropouts in the control group.Apart from conventional western medicine treatment,the control group also received selective5-hydroxytryptamine,followed by the inhibitor Paroxetine.On the basis of treatment administered to the control group,the treatment group also received Shenling Xianxiong Decoction.Before and after the treatment,evaluations based on the Hamilton anxiety scale(HAMA),six-minute walk distance(6MWD),Chinese medicine symptom complex score and COPD assessment test(CAT)were conducted and relevant indicators were compared.Patients’ vital signs were closely observed,adverse reactions were followed and relevant interventions were administered;in the meantime,the safety of the treatment was observed.The treatment lasted 8 weeks.Results:1.A total of 66 patients were enrolled in the research with 33 in the treatment and control groups,respectively.There were no statistically significant differences in basic data(gender,age,course of disease and number of acute exacerbations)between the two groups(P>0.05).2.Anxiety states: The HAMAs of treatment and control groups both dropped after treatment(P<0.05),and the differences in post-treatment HAMA scores were statistically meaningful,with those of the treatment group better than those of the control group(P<0.05).3.Living quality: After the treatment,the CAT scores of the treatment group were significantly lower than before the treatment(P<0.05).The 6MWDs were significantly prolonged after the treatment(P<0.05).Following the treatment,the difference between the treatment and control groups were statistically meaningful,with the efficacy of the treatment group superior to that of the control group(P<0.0).4.Traditional Chinese medicine symptom: After the treatment,both the main(emotional volatile,upset and irritable)and secondary symptoms(Perspiration,fear of wind,easy to catch a cold,,thin loose stool,phlegm sticky yellow or yellow and white)were significantly improved(P<0.05).The difference between the treatment and control groups were statistically meaningful,with the efficacy of the treatment group superior to that of the control group(P<0.05).5.Pulmonary function: The estimated values of FEV1/FVC and FEV1% of the two groups showed no statistically meaningful differences before and after the treatment(P>0.05).Conclusion:Shenling Xianxiong decoction can improve patients’ anxiety states suffering from COPD complicated with anxiety and relieve their traditional Chinese symptoms and increase their living quality.