Correlation Study Of IDDVT Syndrome Type With Color Ultrasound,D-Dimer,CRP And Fib

Purpose: To observe the expression levels of D-Dimer,CRP,Fib and color Doppler ultrasonography in isolated distal deep vein thrombosis(IDDVT)and healthy subjects who underwent physical examination,summarize and analyze the change characteristics of each indicator,provide objective basis for clinical diagnosis of this disease,and analyze the differences of each indicator among different TCM syndrome types.To provide laboratory examination and other objective basis for TCM syndrome differentiation.Methods: Study 1:90 inpatients with IDDVT who met the requirements within a period of time were selected as the observation group,and 30 healthy non-IDDVT outpatients during the same period were selected as the control group.General data(gender,age,etc.)of the two groups were collected.Laboratory indexes such as D-Dimer,CRP and Fib were detected,and lower limb venous color ultrasound was performed to measure the local dilated venous diameter and thrombus site echo intensity in patients with IDDVT.Patients in the observation group were stratified according to gender,age,site of disease,clinical stage,and whether there were inducement factors.The differences in general information and detection indicators between the two groups were compared,the data were analyzed,and the changes of each indicator in IDDVT were summarized and analyzed to explore the diagnostic value of each indicator for IDDVT.Study 2:90 patients meeting the requirements of TCM syndrome differentiation were selected,including 30 cases of dampness-heat syndrome,blood stasis and dampness-heavy syndrome,and spleen-kidney Yang deficiency syndrome respectively.The detection indicators of each syndrome type were counted,the differences among the detection indicators were compared,the characteristics of the corresponding detection indicators of each syndrome type were summarized,and their value in the differential diagnosis of IDDVT syndrome types was explored.Results: In study 1,there was no statistical difference in general data between the control group and the observation group.D-Dimer,CRP,Fib,vascular diameter and other indexes in the observation group were significantly higher than those in the control group(P<0.05).In stratified studies,there were significant differences in the indicators of different clinical stages(P<0.05),IDDVT acute stage D-Dimer,CRP,Fib,thrombus site diameter were higher than subacute stage and chronic stage,subacute stage D-Dimer,CRP,Fib,thrombus site diameter was higher than chronic stage.The echo intensity of color ultrasound was mainly low echo in acute stage,mixed echo in subacute stage and strong echo in chronic stage.Single-factor binary logistic regression analysis showed that D-dimer,CRP,Fib and vascular diameter were independent risk factors for IDDVT.Study 2: In different TCM syndrome types,D-Dimer,CRP,Fib and pipe diameter in damp-heat injection syndrome group were higher than those in blood-stasis and dampness-heavy syndrome group and spleen-kidney Yang deficiency syndrome group(P< 0.05).Compared with the blood stasis and dampness-heavy syndrome group and the spleen-kidney Yang deficiency syndrome group,the thrombi echo intensity in the damp-heat syndrome group was more with low echo(P< 0.05).D-Dimer,CRP,Fib and thrombus site diameter in blood stasis and dampness syndrome group were higher than those in spleen-kidney Yang deficiency syndrome(P< 0.05).Compared with the syndrome of dampness-heat and spleen-kidney Yang deficiency,the thrombi echo intensity in the syndrome of blood stasis and dampness-heavy was more mixed echo(P<0.05).The thrombotic echo intensity of spleen-kidney Yang deficiency syndrome was more than that of dampness-heat syndrome and blood-stasis and dampness-heavy syndrome(P<0.05).Conclusion: D-Dimer,CRP,Fib and color ultrasound are significantly correlated with the occurrence and expression of IDDVT.The expression levels of various indicators in different clinical stages are also different,which has certain diagnostic value for IDDVT.The indications of D-Dimer,CRP,Fib and color Doppler ultrasound are correlated with different TCM syndrome differentiation types,and their expression levels are different under different TCM syndrome differentiation,which have certain auxiliary diagnosis and reference value for TCM syndrome differentiation of IDDVT.