Application Of Ultrasound Parameters In Predicting Ovarian Responsiveness In Patients With Unilateral Ovarian Endometriomas

ObjectiveTo study the ability and correlation of ovarian endometriomas relative volume ratio(OERV)to predict ovarian responsiveness in patients with unilateral ovarian endometriomas undergoing(In vitro fertilization/Intracytoplasmic sperm injection,IVF/ICSI)treatment,and to explore its clinical application value.Materials and MethodsA retrospective analysis of the clinical and imaging findings of 96 infertile patients with unilateral ovarian endometriomas who received IVF/ICSI treatment in the Reproductive and Genetic Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2018 to August 2022 material.All patients underwent transvaginal ultrasonography,and the observations were recorded in detail.The relative volume ratio OERV of OMAs was calculated,and OERV refers to the ratio of the volume of OMAs to the volume of the damaged ovary containing the OMAs.The 96 patients enrolled were divided into three groups according to the OERV value,OERV<30%group(group 1,n=32),OERV≥30%and<50%group(group 2,n=32),OERV≥50%group(group 3,n=32).By analyzing the basic cycle data,cycle characteristics,outcome and other clinical data of patients receiving IVF/ICSI treatment,and comparing the use of relevant predictors(AntiMiillerian hormone,AMH),(Antral Follicle Coun,AFC),(Follicular output rate,FORT),AMH,AFC,FORT,number of dominant follicles,number of retrieved eggs,number of good embryos,etc.to predict ovarian response to evaluate Potential of OERV as an ultrasound parameter to predict ovarian responsiveness in patients with unilateral OMAs.The correlation of OERV with relevant predictors was analyzed.Results(1)AMH,bFSH,damaged ovary AFC,contralateral healthy ovary AFC,damaged ovary FORT,ovarian stimulation program,Gn days,Gn administered,HCG day E2,the number of total oocytes retrieved,2PN,top-quality embryos,There was no significant difference among the three groups(P>0.05),but there was a statistically significant difference in the number of oocytes retrieved from the damaged ovary(P<0.05).(2)There was no significant difference in AFC between the damaged ovary and the contralateral healthy ovary in the three groups(P>0.05).(3)There was no significant difference in the number of follicles retrieved and FORT between the damaged ovary and the contralateral healthy ovary in the OERV<30%group(P>0.05),but the number of mature follicles was reduced(4.6±2.5 vs 6.3±3.0,P=0.023).(4)In the OERV≥30%and<50%group,compared with the contralateral healthy ovary,FORT was significantly lower in the damaged ovary(41.4%vs 57.3%,P=0.002),and the number of mature follicles was significantly decreased(4.9±3.1 vs 6.9±3.6,P=0.007),and the number of oocytes retrieved decreased(4.9±2.5 vs 7±3.3,P=0.004).(5)In the OERV≥50%group,the FORT of the damaged ovary was significantly lower than that of the contralateral healthy ovary(41.4%vs 57.3%,P=0.002),and the mature follicles were significantly reduced(3.512.2 vs 6.3±3.2,P=0.000),the number of oocytes was significantly reduced(3.3±2.1 vs 6.9±3.4,P=0.000).(6)There was no significant correlation between OERV and AMH,the total number of oocytes retrieved,and 2PN(P>0.05),and there was a negative correlation between OERV and the number of oocytes retrieved in damaged ovaries(r=-0.284,P=0.005).ConclusionInfertility patients with unilateral OMAs can use the ultrasound parameter OERV as an index to predict ovarian responsiveness,and the OERV value of 30%is used as a cut-off value for predicting the reduced responsiveness of the damaged ovary,but the size of the OERV value does not affect the overall ovarian responsiveness and embryos quality.