Observation On The Efficacy And Safety Of Postoperative Treatment With Cyclosporine Eye Drops In Cataract Patients Comorbid With Mild To Moderate Dry Eye

Objective:To observe the efficacy and safety of postoperative treatment with cyclosporine eye drops in cataract patients comorbid with mild to moderate dry eye.Methods:A total of 60 patients diagnosed with cataract comorbid with mild to moderate dry eye and receiving phacoemulsification surgery in Shandong Provincial Hospital from July 2022 to December 2022 were enrolled.They were divided into experimental group and control group according to random number table,with 30 cases in each group.Other postoperative routine medication to ensure consistency.In the postoperative 7d,Experimental group received 0.05%cyclosporine eye drops(Ⅱ)after surgery,1 drop/time,twice/day.Control group received 0.1%sodium hyaluronate eye drops after surgery,1 drop/time,twice/day.Both groups were treated for 3 months and maintained follow-up.Break up time of tear film(BUT),corneal fluorescence staining score(CFS),Schirmer Ⅰ test(SIt)score and ocular surface disease index(OSDI)of both groups were measured and statistically analyzed in the preoperative and postoperative 7d,30d,90d respectively.The safety was evaluated by observing ocular adverse reactions occurred after medication in two groups.Results:There was no significant difference in general information between 2 groups(P>0.05).There was no significant difference in preoperative baseline values(P>0.05).The BUT were(6.93 ± 1.79)seconds and(8.27±1.76)seconds in postoperative 30d,90d in the experimental group,which were longer than(5.81±1.75)seconds in postoperative 7d(both at P<0.001);those in the control group were(6.16±2.02)seconds and(7.07±2.37)seconds in postoperative 30d,90d,with significant extension in comparison with postoperative 7d(5.50±1.78)seconds(both at P<0.001).The BUT was significantly longer in the experimental group compared with the control group in postoperative 90d(P=0.027).The CFS were(2.63± 1.22)and(1.07±0.91)in postoperative 30d,90d in the experimental group,which were lower than(3.80±1.27)in postoperative 7d(both at P<0.001);those in the control group were(2.77±1.17)and(1.60±0.86)in postoperative 30d,90d,with significant reduce in comparison with postoperative 7d(3.87±1.55)(both at P<0.001).The CFS was significantly lower in the experimental group compared with the control group in postoperative 90d(P=0.023).The SIt were(6.33±2.44)mm and(7.87±1.93)mm in postoperative 30d,90d in the experimental group,which were longer than(5.10±2.40)mm in postoperative 7d(both at P<0.001);those in the control group were(5.90±2.14)mm and(6.73±2.23)mm in postoperative 30d,90d,with significant extension in comparison with postoperative 7d(5.07±2.20)mm(both at P<0.001).The SIt was significantly longer in the experimental group compared with the control group in postoperative 90d(P=0.039).The OSDI were(28.07±8.52)and(19.02±5.59)in postoperative 30d,90d in the experimental group,which were lower than(33.53±8.45)in postoperative 7d(both at P<0.001);those in the control group were(29.63±6.52)and(23.03±7.42)in postoperative 30d,90d,with significant reduce in comparison with postoperative 7d(34.50±5.49)(both at P<0.001).The OSDI was significantly lower in the experimental group compared with the control group in postoperative 90d(P=0.021).Conclusion:For cataract comorbid with mild to moderate dry eye patients,the use of 0.05%cyclosporin eye drops(Ⅱ)after cataract phacoemulsification can effectively increase the break up time of tear film,enhance the stability of tear film,promote the repair of corneal epithelium,relieve dry eye symptoms,increase the basic secretion of tear,improve the quality of life of patients,and is safe and reliable.And with the extension of use time,the therapeutic effect will be more significant.