| Objective: The purpose of this study was to investigate the impact of C-reactive protein(mg/L)and albumin level(g/L)ratio(CAR)on the short-term prognosis of patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI),in order to identify such high-risk populations with short-term recurrence of major cardiovascular and cerebrovascular adverse events(MACE),and further clarify the role of C-reactive protein/albumin ratio,an inflammatory indicator in cardiovascular disease,To identify its impact on the short-term prognosis of patients with STEMI after PCI,find an economic,practical,and convenient reliable basis for the occurrence of dangerous events in patients after PCI,and promptly conduct early intervention to prevent the occurrence of adverse cardiovascular events in advance,improve the quality of life of STEMI patients,and improve their prognosis.Although the prognostic effectiveness of CAR has previously been associated with poor prognosis in STEMI patients,to our knowledge,the short-term prognostic effectiveness of CAR in STEMI patients after PCI has not been studied.Therefore,this study aims to explore the potential therapeutic value of CAR in predicting the short-term prognosis of STEMI patients after PCI.Methods: The experimental group selected 152 STEMI patients who received PCI treatment in the Affiliated Hospital of Jining Medical College from January 2020 to June 2021.Upon admission,a 12-lead electrocardiogram examination was performed,combining symptoms and myocardial markers to confirm the patient’s STEMI.Collect blood samples from patients before PCI,including blood biochemistry,myocardial infarction,blood routine,blood coagulation,etc.Used to measure levels of CRP,albumin,and cardiac troponin.Age,gender,smoking history,vital signs,electrocardiogram,onset symptoms,duration of symptoms,CRP/albumin ratio at first admission,coronary angiography,and PCI results(number of vascular lesions,and degree of stenosis)were determined.The patients with MACE(sudden cardiac death,heart failure,malignant arrhythmia,recurrent non fatal myocardial infarction,recurrent angina pectoris,and recurrent target vessel revascularization)events within 6 months after PCI were statistically analyzed.According to whether cardiovascular events occurred,they were divided into a MACE group of 35 patients and a non MACE group of 117 patients.To analyze the relationship between the CRP/albumin ratio at first admission and MACE events occurring within 6 months after PCI,and to screen independent risk factors for recurrent cardiovascular and cerebrovascular events in patients with acute myocardial infarction after emergency PCI,to identify the risk of MACE events occurring shortly after PCI in STEMI patients.To provide reference for identifying patients at high risk after PCI.Results:1.The age and length of hospitalization of the MACE group were higher than those of the non MACE group,and the total cholesterol,low density lipoprotein,and LVEF of the MACE group were lower than those of the non MACE group,with significant differences(P<0.05).2.Compared with the two groups of patients before PCI,C-reactive protein,serum albumin,and CAR in the MACE group were higher than those in the non MACE group,with a statistically significant difference(P<0.05).3.The statistically significant univariate analysis of C-reactive protein,CAR,total cholesterol TC,low density lipoprotein(LDL-C),LVEF,stenosis degree,cardiac function grade,and age detected for the first time before PCI were included in the multivariate logistic regression analysis.Increased CAR is an independent risk factor for the recurrence of major cardiovascular and cerebrovascular adverse events in STEMI patients after PCI.(OR=8.594,95%CI:1.621-45.546,P=0.011)。4.The ROC curve analysis results suggest that the AUC of CAR for predicting the recurrence of major cardiovascular and cerebrovascular adverse events in patients with STEMI after PCI is 0.656 ± 0.064(95%CI: 0.574-0.731,P=0.014).The optimal cutoff point is 0.301,with a sensitivity of 46.67% and a specificity of 88.43%.Conclusion: The higher the CRP/ALB value of STEMI patients treated with PCI,the more prone they are to recurrent cardiovascular and cerebrovascular events,which is an independent risk factor for the recurrence of cardiovascular and cerebrovascular disease events,and has good predictive power.In summary,elevated CAR levels are associated with an increased risk of MACE after PCI in STEMI patients.As a widely used parameter by clinicians,CPR may be a cheap tool for identifying the risk of MACE events occurring shortly after PCI in STEMI patients.CAR is a newly introduced inflammatory based risk index that has been found to be a potentially useful prognostic tool for predicting poor prognosis in STEMI patients.However,this finding needs to be validated in future prospective studies. |
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