| Objective: The purpose of this project is to investigate the value and significance of the GUI Kidney Fuzheng Granules in the treatment of gynecological malignant tumor diseases by observing the clinical efficacy of GUI Kidney Fuzheng Granules in the treatment of gynecological malignant tumor complications after surgery and chemotherapy,so as to provide a reference basis for clinical promotion.Methods: From October 2020 to October 2022,60 patients who underwent surgery for gynecological malignancies(preoperative non-menopausal,intraoperative removal of bilateral adnexa and uterus)and chemotherapy after surgery were collected from the Department of Gynecology of our hospital(Affiliated Hospital of Traditional Chinese Medicine,Southwest Medical University),and the enrolled cases were divided into a treatment group(30cases)and a control group(30 cases),with 17 cases of ovarian cancer,2 cases of endometrial cancer and 11 cases of cervical cancer in the treatment group,middle age: 46.30 ± 3.84 weeks;the control group includes 17 cases of ovary cancer,intrauterine cancer 2 cases,cervical cancers 11 cases,middle ages:46.83 ± 4.50 years.The age,body weight,body mass index(BMI),number of pregnancies,type of tumor,pre-KPS treatment scores were recorded at the time of the treatment group and the control group.Patients in the control group were treated with TC chemotherapy regimen for standardized treatment;in the treatment group,the combination of the TC chemotherapy regimen with the use of Returning Kidney Fu Zheng granules(no-decoction granules configured by the pharmacy of our hospital).,from the beginning of the first day of the chemotherapie,oral renal Remediation Pills,once,three times a day,orally 21 days after the treatment.After the start of the treatment,regular follow-up to the group patients to record the relevant signs of life,adverse reactions to the drug,and to the two groups of patients before treatment endocrine hormone levels(E2,FSH),blood normals,liver function and other relevant test indicators to be determined,at the same time,for the two group of patients prior treatment,Kupperman rating,survival quality rating and medical certificate score to be quantified.Finally,data statistical analysis is carried out using SPSS 26.0software.Results:1.Comparison of pre-treatment baseline data(age,body weight,BMI,number of pregnancies,type of tumor,KPS score)between the treatment group and the control group was comparable,with no noticeable difference(P>0.05).2.Differences in test indicators,quantitative scores,and adverse reactions between the two groups of patients were compared as follows:1)Endocrine :(1)comparison of estrogen(E2): there is no noticeable difference between E2 levels before treatment in the two groups of patients(P>0.05);the levels of E2 in both groups have declined after treatment,but the decrease in E2 level is lower than in the control group,the treatment group has declined from23.30 ± 6.76 before treatment to 20.62 ± 5.90,the controlling group has decreased from 24.21 ±5.39 before therapy to 17.37 ± 4.65,and the comparison between the differences between the treatment groups 7 days,14 days and 21 days is statistically significant(P<0.05).(2)Comparison of FSH: There were no noticeable differences in FSH levels prior to treatment in the two groups(P>0.05);after-treatment levels increased in both groups,but the level increase in the FSH level was lower than in the control group,the treatment group increased from 49.81 ± 10.21 before treatment to 53.48 ± 12.35,the controlled group increases from 48.10 ±10.25 prior to therapy to 60.99 ±12.26,and the comparison of differences after 7 days,14 days,and 21 days between the two treatment groups is statistically significant(P<0.05).2)Blood count: The white blood cell count(WBC),platelet count(PLT)and haemoglobin(HB)were compared between the two groups on days 7,14 and21,respectively,and it was found that the WBC count in the two groups first decreased and then gradually rebounded after chemotherapy,where the leukocyte count in the treatment group was higher than that in the control group on day 7 of treatment(3.66±0.86 vs.3.11±0.85),and the difference between the groups was statistically significant(P<0.05);meanwhile,the total haemoglobin in the treatment group was higher than that in the control group on day 7 of treatment(105.33±11.92 vs.(99.92±11.07),and the difference between the groups was statistically significant(P<0.05).3)The treatment group and the control group had no noticeable differences in symptom scores before treatment(P > 0.05),the differences were not statistically significant;after treatment,the treatment group had lower symptoms scores than the control(5.70±1.21 vs.6.80±1.79),the difference was noticeable,and had statistical significance(P<0.05);in terms of effectiveness,the efficacy of the therapeutic group was significantly higher than that of the controlling group(87% vs.57%),and the difference had statistic significance(P<0.05).4)Individual scores for fluorescent sweat: comparison of fluorescence sweat scores between the treatment group and the control group before treatment,with no statistically significant differences(P > 0.05);after treatment,fluorescence sweats scores were lower than in the controlling group(3.60±1.92 vs.4.67±1.52),and the differences were noticeable and of statistical significance(P<0.05).5)Kupperman scores: comparison of pre-treatment,treatment group and control group’s Cupperman symptom scores,with no statistically significant differences(P>0.05);after treatment,the treatment group scores were lower than the control group(14.84±5.59 vs 17.97±4.77),with noticeable differences and statistical significance P<0.05).6)Survival quality: compared with two groups of patients,the survival mass score before treatment,no noticeable difference,P > 0.05,no statistical significance;the scores in the various fields after the treatment of the two groups decreased,but the treatment group scores lower in body function,psychological function and specific modules compared to the control group,and the difference is significant and statistically significant(P<0.05);and the overall survival quality score after treatment is higher than the controlling group(56.19±16.17 vs 48.20±14.95),the difference has a statistic significance(P<0.05).7)Side effects: comparison of common symptoms and side effects points of the two groups in the gynaecological malignant tumor survival mass table,compared with no obvious differences before treatment;after treatment,the treatment group’s common symptom and side effect points are higher than the control group(reverse score),the difference is of statistical significance(P<0.05);the two group in the common side effects(nausea,diarrhoea,constipation)comparison,the number of adverse reactions after chemotherapy two groups are more than before treatment,but the comparison between the numbers of cases of nausea and vomiting from two groups is significantly lower than the controlled group(12 cases vs 24 cases),and the severity of the patient’s "nudge vomiting" is also lower than in the controlling group,the differences are statistically significant(P<0.05).8)Safety Indicators: Treatment group and control group pre-treatment liver function indicators: glutathione(AST),grapefruit transaminase(ALT),kidney function indicator: serum myeloma(CR)measurement has no obvious abnormalities.Comparison between groups prior to treatment,differences are not obvious,no statistical significance(P>0.05).Conclusion: GUI Kidney Fuzheng Granules can improve the clinical symptoms of menopause in gynaecological malignant tumour patients after ovariectomy,alleviate nausea and vomiting caused by chemotherapy,and improve the quality of survival of patients in terms of physical,psychological and emotional aspects.The present study corroborates the toxicity-reducing and efficacy-enhancing effects of Chinese medicine in the treatment of gynaecological malignant tumour diseases,but the specific mechanism of improving menopausal symptoms and alleviating the side effects of chemotherapy is still unclear and needs to be further explored in the next studies. |
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