Based On The Theory Of "Collateral-Disease" To Explore The Clinical Effect Of Tongluo Xiaozhong Prescription Combined With Aescuvenforte Tablet In The Treatment Of Lower Limb Lymphedema After Cervical Cancer Surgery

Objective: Based on the "collateral disease theory",the self-designed Tongluo Xiaozhong prescription was used to treat lower limb lymphedema of damp-stasis obstructing collaterals type,and observed the symptoms and signs as well as the changes of fibrinogen before and after treatment to investigate its clinical efficacy and safety.Methods: Sixty patients who met the inclusion criteria were selected as research objects,and the subjects were divided into observation group and control group by random number table method,with 30 subjects in each group.The control group was given aescuven forte tablet on the basis of functional exercise,and the observation group was treated with Tongluo Xiaozhong prescription combined with aescuven forte tablet.The treatment cycle was 21 days.Limb circumference difference,gynecological cancer lymphedema questionnaire(GCLQ)score,TCM symptom score,serum fibrin(FIB)level and safety indexes were recorded before and after treatment,and the data were statistically analyzed.Results:(1)The peripheral diameter difference of limbs:(1)Comparison between groups: After treatment,the peripheral diameter difference of observation group at the dorsal foot,lateral malleolus,10 cm below the upper margin of patella,the superior patellar border and 10 cm above the superior patellar border were lower than that of control group(P<0.05);(2)Intra-group comparison: Compared with the pre-treatment period,the limb circumference difference was reduced in both groups at all locations(P<0.05).(2)GCLQ scores:(1)Comparison between groups: after treatment,in terms of heaviness,edema(overall),swelling(local),pain,limb function scores and total scores,the GCLQ scores of the observation group were lower than those of the control group(P<0.05),but regarding numbness and infection scores,the differences were not statistically significant when comparing the two groups(P>0.05);(2)Comparison within groups: GCLQ scores were significantly lower in both groups after treatment compared to pre-treatment(p<0.001).(3)TCM syndrome score and TCM syndrome efficacy:(1)Comparison between groups: the TCM symptom score of the observation group was lower than that of the control group compared to pre-treatment(P<0.01);the cure and efficiency rate of the observation group were higher than those of the control group(P<0.01);(2)Comparison within groups: the TCM symptom scores of both groups were significantly reduced after treatment(P<0.001).(4)FIB index:(1)Comparison between groups: after treatment,the FIB level of the observation group decreased than that of the control group(P<0.05).(2)Intra-group comparison: The FIB level in both groups were lower after treatment Compared with before treatment(P<0.001).Conclusion: Based on the "collateral disease theory",the use of Tongluo Xiaozhong prescription can reduce the circumference difference of both lower extremities,improve the clinical symptoms and signs of patients,and reduce the fibrinogen content in the serum of patients,which can effectively treat lymphedema of lower extremities after cervical cancer surgery.