Study On Sleep Disorder Related Factors And Diffusion Tensor Imaging In Adult Patients With Epilepsy

Objective:1.To evaluate the demographic and clinical characteristics in adult patients with epilepsy(PWE)with sleep disorders.2.To analyze the prevalence and correlative factors of sleep disorders in PWE.3.To preliminarily explore the possible change of cerebral white matter underlying the sleep disorders in PWE.Methods:A total of 100 definite clinical diagnosed PWE from the Department of Neurology of Affiliated Hospital of North Sichuan Medical College were consecutively recruited in this cross-sectional study between January 2021 and December 2021.Pittsburgh Sleep Quality Index(PSQI)was used to access the sleep quality.The global cognitive function was evaluated using Montreal Cognitive Assessment(MoCA).Anxiety was assessed using the Hamilton Anxiety Scale(HAMA).Depression was assessed using Hamilton Depression Scale(HAMD).The social support rate was assessed using Social Support Rating Scale(SSRS).Part of the recruited patients completed the MRI scan which included diffusion tensor imaging.Results:(1)In this study,24 cases(24.0%)of PWE presented with sleep disorders.(2)The age,education level,married rate,HAMA score and HAMD score in the epilepsy with sleep disorders group were higher than those in the epilepsy with non-sleep disorders group;the MoCA score was lower in the epilepsy with sleep disorders group than that in the group without sleep disorders.(3)No significant differences in gender,employment,age of onset,course of disease,etiology,seizure type,seizure frequency,duration of epilepsy,number of antiepileptic drugs(AEDs)and family history were found between PWE with and without sleep disorders.(4)Binary Logistic regression analysis showed that HAMD score and age were positively correlated with sleep disorders in PWE.(5)There was no significant difference in fractional anisotropy(FA)value and mean diffusivity(MD)value between epileptic patients with sleep disorders and epileptic patients without sleep disorders.Conclusion:(1)Sleep disorders were common in epilepsy patients in this region,with a prevalence rate of 24.0%.(2)Age,marriage,education level,anxiety,depression and cognitive impairment may be correlated with sleep disorders in PWE,meanwhile age and depression were independent correlation factors of sleep disorder in PWE.(3)Gender,employment,age of onset,course of disease,etiology,seizure type,seizure frequency,duration of epilepsy,number of AEDs and family history may not be related to sleep disorder in PWE.(4)Sleep disorders of PWE may not cause or aggravate the damage of white matter in the brain,which needs further study in the future.