Expression Level And Clinical Significance Of IL-1β And IL-18 In Serum Of Children With Kawasaki Disease

Objective:To investigate the expression level and clinical significance of IL-1β and IL-18 in serum of children with Kawasaki disease.Methods:There are 60 children with Kawasaki disease in the department of Pediatrics of The Affiliated Hospital of North Sichuan Medical College from June 2020 to October 2021 were enrolled as Kawasaki disease group.30 cases of pneumonia in the same period were fever control group.And 20 healthy children were included in the normal control group.Fasting venous whole blood of children in each group was collected,and the level of interleukin-1β(IL-1β)and interleukin-18(IL-18)in serum were determined by enzyma-linked immunosorbent assay(ELISA assay),and the clinical data were statistically analyzed to explore the clinical significance of IL-1β and IL-18 in the diagnosis and treatment of children with Kawasaki disease.Results:(1)The levels of IL-1β and IL-18 in Kawasaki disease group and fever control group were significantly higher than those in normal control group(P<0.05),and those in Kawasaki disease group were slightly higher than those in fever control group,the difference was not statistically significant(P>0.05).Univariate Logistic regression analysis showed that IL-1β and IL-18 were not associated with pneumonia(P=0.998,0.998).Increased IL-1β was a risk factor for KD(OR=3.664,P=0.015),while IL-18 was not associated with KD(OR=1.287,P=0.213).(2)The IL-1β and IL-18 in CAL group were significantly higher than those in NCAL group(P<0.05).Univariate Logistic regression analysis showed that increased IL-1β and IL-18 were risk factors for CALs(OR=2.143,P=0.008;OR=1.257,P=0.017).Conclusion:The serum levels of IL-1β and IL-18 in children with Kawasaki disease were increased,and the increase of serum IL-1β was a risk factor for Kawasaki disease.The serum levels of IL-1β and IL-18 in children with KD combined with CALs are more significant,which are high risk factors for CALs.