Correlation Between Left Ventricular Hypertrophy And Mean Platelet Volume In Non-dialysis CKD Patients

Objective:To investigate the correlation between left ventricular hypertrophy(LVH)and mean platelet volume(MPV)in non-dialysis chronic kidney disease(CKD)patients.Methods:A retrospective analysis was performed on 180 non-dialysis CKD patients diagnosed in the Department of Nephrology,Affiliated Hospital of North Sichuan Medical College from January 2021 to December 2021.According to LVH diagnostic criteria,the included patients were divided into LVH group and non-LVH group.The general data,laboratory indexes,and cardiac color Doppler ultrasound results were collected and compared between the two groups.Body mass index(BMI),body surface area(BSA),estimated glomerular filtration rate(eGFR),left ventricular mass(LVM)and left ventricular mass index(LVMI)were calculated according to relevant formulas.Spearman correlation analysis was used to clarify the correlation between MPV and LVMI.At the same time,binary logistic regression was used to analyze the risk factors of LVH and receiver operating characteristic curve(ROC)to evaluate the predictive value of MPV and other factors for the occurrence of LVH in non-dialysis CKD patients.Results:1.A total of 180 eligible non-dialysis CKD patients were included,ranging in age from 19 to 87 years old,with an average age of 53.69±14.54 years.There were 73 patients(40.6%)with LVH,including 30 males(41.1%)and 43 females(58.9%);107 patients(59.4%)without LVH,including 69 males(64.5%)and 38 females(35.5%).The probability of LVH in patients with CKD 1-2,CKD 3,CKD 4,and CKD 5 was 19.5%,36.4%,41.2%,and 62.0%,respectively.2.Systolic blood pressure,diastolic blood pressure,mean platelet volume,triglyceride,urea nitrogen,serum creatinine,cystatin C,blood calcium,blood magnesium,blood phosphorus and parathyroid hormone in LVH group were higher than those in non-LVH group,while male composition ratio,hemoglobin and albumin levels were lower than those in non-LVH group,the differences were statistically significant(P<0.05).3.Spearman correlation analysis showed that MPV and systolic blood pressure were positively correlated with LVMI.4.Binary logistic regression analysis showed that female(OR=5.272,P=0.001),systolic blood pressure(OR=1.051,P<0.001),and MPV(OR=2.067,P<0.001)were the risk factors for LVH in non-dialysis CKD patients.5.OC analysis showed that the areas under the curve of MPV,systolic blood pressure,and MPV combined with systolic blood pressure for predicting the occurrence of LVH in non-dialysis CKD patients were 0.765(95%CI 0.644～0.793,P<0.001),0.719(95%CI 0.696～0.833,P<0.001),0.910(95%CI 0.870～0.950,P<0.001)Conclusion:1.LVH can occur in the early stage of non-dialysis CKD patients,and its incidence increases with the decrease of eGFR.Therefore,delaying the decline of renal function can effectively reduce the occurrence of LVH.2.Female gender,high systolic blood pressure,and high MPV level increase the risk of LVH in non-dialysis CKD patients,and MPV has a certain diagnostic value for non-dialysis CKD patients with LVH.3.Using systolic blood pressure combined with MPV to predict the occurrence of LVH in non-dialysis CKD patients is more valuable than using MPV and systolic blood pressure alone.