Study On The Correlation Between Total MRI Load Of Cerebral Small Vessel Disease And Vestibular Function

Objective:To investigate the correlation between total MRI load of cerebral small vessel disease and vestibular function.To understand the relationship between cerebral small vessel disease(CSVD)and vestibular function,and to identify the clinical manifestations of vestibular-related diseases due to CSVD at an early stage,in order to provide more reference basis for early intervention and clinical research of CSVD patients.Methods:The study collected 115 patients of CSVD with dizziness who were aged ≥60 years by meeting the inclusion and exclusion criteria.All enrolled patients received a detailed medical history and specialized neurological physical examination,and recorded the characteristics of the patients’ clinical presentation.All patients completed multimodality cranial MRI,including conventional T1 WI,T2WI,FLAIR,DWI and SWI,and then the imaging manifestations characteristic were analyzed in each case,that include the frequency and degree of lacunar infarction(LI),white matter hyperintensity(WMH),cerebral microbleed(CMB)and perivascular space(PVS),and the CSVD total load scale was used for evaluation.The patients of CSVD were separateed into three groups according to the score: mild group(0 points),moderate group(1 to 2 points)and severe group(3 to 4 points).All patients underwent vestibular function examination,including spontaneous nystagmus,optic eye movement examination,position test,temperature test,and V-HIT examination,and the results of each patient were recorded.Finally,statistical analysis was performed to determine whether there were differences in vestibular function results between the 3 groups of patients,and to further understand the relationship between total MRI load of CSVD and vestibular function.Results:1.In this study,related the general clinical data of the 3 groups,it was found that the age of the severe group was higher than that of the mild and moderate groups,and the difference was statistically significant(P<0.05),further correlation analysis showed that age was positively correlated with the total CSVD load score.There was no statistically significant differences(P>0.05)in the baseline data of gender,hypertension,and diabetes mellitus among the groups.2.The incidence of vestibular abnormalities(central and peripheral vestibular),peripheral vestibular abnormalities and positional nystagmus abnormalities in the moderate group(1 to 2points)was higher than in the other two groups,and the differences were statistically significant(P<0.05),there were no statistical differences in spontaneous nystagmus,temperature test,and central nystagmus among the three groups(P>0.05).3.Patients of CSVD had a total load score of 0 was33 cases(28.69%),1 was 23 cases(20.00%),2 was 29 cases(25.22%),3 was 19 cases(16.52%),and 4 was 11 cases(9.57%);Binary logistic regression of factors affecting vestibular function showed that total MRI load of cerebral small vessel disease was an independent risk factor for abnormal vestibular function(OR 值=1.476,95%CI=1.043-2.089;P=0.028<0.05).Conclusions: 1.Age is correlated with the total MRI load of cerebral small vessel disease.2.There is a correlation between the total MRI load of and vestibular function.3.The total MRI load of cerebral small vessel disease may be a risk factor for abnormal vestibular function(central and peripheral vestibules).