Correlation Between Serum PCT,CRP,SAA And BODE Index In Patient With AECOPD In Xining Area

Objective:By detecting serum levels of procalcitonin,C-reactive protein and serum amyloid A in patients with AECOPD in Xining area combined with the score of BODE index,the correlation between serum levels of PCT,CRP,SAA and BODE index in patients with AECOPD was discussed.The severity and prognosis of AECOPD were evaluated according to PCT,CRP,SAA and BODE index,as well as the correlation between the number of hospital stays,the number of acute exacerbations and the BODE index score in patients with acute exacerbations of COPD within 1 year.To provide guidance for the severity and prognosis of patients with AECOPD in Xining region.Methods:A total of 102 patients admitted to The Affiliated Hospital of Qinghai University from September 2020 to January 2021 who underwent lung function test and were definitely diagnosed as AECOPD were collected.Meanwhile,BMI,6MWD and MMRC questionnaires were improved and divided into two groups according to BODE index score:20 patients in group I（0-2 points）and 26 patients in group II（3-4 points）.There were 26 cases in group III（5-6 points）and 30 cases in group IV（7-10 points）.General data of the patients were collected,blood gas was analyzed on admission,and the level of fasting blood PCT CRP SAA in the morning was statistically analyzed.Results:1.There were no significant differences in gender,smoking, drinking,age and BMI among all groups（P>0.05）.There were statistically significant differences in medical history,acute aggravation times within 1 year and hospitalization times within 1 year among the four groups（P<0.05）.2.In BODE group of AECOPD patients,Pa CO₂ in group IV increased significantly compared with group I,group II and group III,and Pa CO₂ in each group of AECOPD had statistical significance（P<0.05）;In BODE group,PCT,CRP and SAA increased significantly in group IV compared with group I,group II and Group III,and there were statistically significant differences in PCT,CRP and SAA among AECOPD groups（P<0.05）.There was no significant difference between Pa O₂ and Sa O₂（P>0.05）.3.FEV₁,FVC,FEV₁/FVC and FEV₁%pred values of AECOPD patients in group IV were the lowest,which were significantly lower than those in group I,group II and group III,and the differences were statistically significant（P<0.05）.4.PCT,CRP,SAA were positively correlated with BODE index in AECOPD patients.5.PCT,CRP and SAA were not correlated with BMI in BODE index,but positively correlated with MMRC,and negatively correlated with FEV1%pred and 6MWD.6.The number of exacerbations and hospitalization within one year were positively correlated with BODE index.Conclusion:1.The levels of PCT,CRP and SAA in AECOPD patients increased with the increase of BODE index score,which were positively correlated with BODE index;2.PCT,CRP and SAA can reflect the severity of AECOPD patients,and can also be combined with BODE index to evaluate the severity and prognosis of AECOPD patients;3.There was a positive correlation between the number of hospitalizations within 1 year and the number of acute exacerbations within 1 year and BODE index,and the higher the BODE index score of the number of hospitalizations within 1 year and the number of acute exacerbations within 1 year,the more severe the condition of AECOPD was.