Study On The Correlation Between Benign Thyroid Nodule And Differentiated Thyroid Carcinoma And Renal Function

Objective:By exploring the clinicopathological correlation between benign thyroid nodules and differentiated thyroid cancer and renal function,this study provides clinical basis for further analysis of the internal relationship between renal function and differentiated thyroid cancer,so as to clearly observe the preoperative renal function of patients to help determine benign and malignant tendencies of thyroid cancer patients.Further,the proposed surgical methods and prognosis of thyroid tumor patients were determined to guide the individualized diagnosis and treatment of thyroid tumor patients,in order to reduce tumor recurrence and improve prognosis.Methods:A total of 184 patients with benign thyroid nodules and 139 patients with differentiated thyroid cancer who met the inclusion and exclusion criteria of this study were collected from the Department of Surgery of Extratomatous second mammary gland and Thyroid in Qinghai University Affiliated Hospital from July 2019 to July2021.The data were collected and sorted out.Pathology reported that patients with differentiated thyroid cancer were the observation group and patients with benign thyroid nodules were the control group.The relationship between the general data of the two groups was compared,and then the relationship between the renal function of the two groups was compared.The influence of general data on uric acid level was again compared between the two groups.Subgroup analysis was performed in patients with differentiated thyroid cancer according to pathological classification,clinical stage of tumor and presence of lymph node invasion,and the relationship of uric acid among subgroups of patients with differentiated thyroid cancer was compared.Results:By comparing the general data of patients in the two groups,there was no statistical difference in gender,height,weight,BMI,ethnicity,marital status and family history of thyroid cancer between the two groups(P>0.05),but there was a statistical difference in the distribution of onset age between the two groups(Z=-5.046,P<0.05).There was a statistical difference in education level between the two groups(χ~2=38.264,P<0.05),and there was a statistical difference between the primary school and illiterate group and the middle school,high school,college and above group(P<0.05).Comparison of renal function test data between the two groups showed that there were no significant differences in serum creatinine,urea nitrogen and cystatin C between the two groups(P>0.05),and uric acid in the observation group(358.10±64.43)was significantly higher than that in the control group(285.92±71.39).The difference was statistically significant(t=-9.378,P<0.05).By comparing the two groups of patients with general information on the effect of uric acid,found in the two groups of patients age,marital status,educational level,tumor diameter has no obvious effect on uric acid differences(P>0.05),in terms of gender,male patients in two groups of patients,on average,uric acid levels higher than that of female patients,differences statistically significant(F=21.456,P<0.05).In terms of ethnicity,the average uric acid level of non-Han patients in the two groups was higher than that of Han patients,with statistical significance(F=12.983,P<0.05).By comparing the observation group and the group of data on the influence of uric acid,found in pathological classification and lymph nodes with and without violation of no significant difference(P>0.05),and compared in terms of stages,stage II differentiated thyroid cancer significantly better than the average level of uric acid in patients with stage I differentiated thyroid cancer patients,statistically significant difference(t=-5.307,P<0.05).Conclusion:Through the comparison of renal function levels between benign thyroid nodules and differentiated thyroid cancer in this study,the conclusions are as follows:1.Compared with patients with benign thyroid nodules,patients with differentiated thyroid cancer were younger and had higher education;2.Compared with patients with benign thyroid nodules,the average level of renal uric acid in patients with differentiated thyroid carcinoma was higher;3.The average level of renal uric acid in male patients with differentiated thyroid cancer was more significant than that in female patients,and that in non-Han patients was more significant than that in Han patients;4.The higher the average level of renal uric acid in patients with differentiated thyroid cancer,the later the clinical tumor stage.