Meta-analysis And Medication Rules Of Traditional Chinese Medicine Compound Treatment For Diarrhea-type Irritable Bowel Syndrome

ObjectiveA meta was conducted on a RCT of TCM compound treatment of IBS-D,and the medication regularity for the treatment of IBS-D were excavated,so as to provide reference for clinical use.MethodsRetrieved CNKI,Wan Fang,VIP,CBM,Pub Med,The Cochrane Libray,EMbase Database,collected RCT of TCM compound treatment of IBS-D,limited to January 1,2010 to October 31,2021,and screened literature according to napai standards.Extracte data,assesse quality,and analyze using Rev Man 5.3.The search for studies on the compound treatment of diarrhea-type irritable bowel syndrome in the three databases of CNKI,Wan Fang Data,and Wipro Chinese Scientific and Technological Journals Database(VIP),the search time:January 1,2017 to July 31,2021,including randomized controlled trials,expert experience and other literature,the formula was entered into Excel,and the SPSS modeler was used for analysis.Results1.Meta-analysis included a total of 32 literature,including 3276 subjects,including 1642 in the experimental group and 1634 in the control group,and the data analysis results show that:Effective rate: RR = 1.26,95%CI [1.23,1.30],P < 0.00001.It is that efficacy of TCM treatment group is better than Western medicine treatment group,and there is significant difference.Abdominal pain symptom score: Result: SMD=-1.66,95% CI [-2.37,-0.94],P<0.00001,indicating that TCM group is better than Modern physic in alleviating abdominal pain,and there is a statistical difference.Abdominal distention symptom score: The results suggest that SMD=-0.91,95%CI [-1.11,-0.72],P<0.00001,indicating that adjuvant TCM treatment can improve abdominal distension symptoms,there is a statistical difference.Stool number integration: The results suggest: SMD=-2.04,95%CI [-3.18,-0.90],P=0.0005<0.05,indicating that Chinese medicine can reduce the number of stools,there is a statistical difference.Recovery: The results suggest: RR=1.80,95% CI [1.52,2.13],P<0.00001,indicating that adjuvant treatment of traditional Chinese medicine is better than the modern physic group,and there is a statistical difference.Recurrence: The results show that the recurrence of Chinese medicine compound is lower than that of the Western medicine group,and there is a statistical difference between RR=0.20,95% CI [0.12,0.32],P<0.00001.Adverse reactions: a total of 54 people in 6 literatures had adverse reactions,mainly dizziness and headache,which were mild and quickly relieved.In the study of Ren Hezhuang and Huang Yong,the incidence of adverse reactions in the test group was lower than that in the control group(the difference was statistically significant),and there was no significant difference between the two groups in the other 4literatures(no statistical significance).2.The 332 articles on the treatment of IBS-D were retrieved,involving 337 prescriptions,the results :(1)The 5 flavor drugs before taking the drug are baizhu,licorice,white peony,poria and tangerine peel,which are mainly tonic drugs,and the drugs are mainly flat,warm,spicy,sweet and bitter,and the spleen is the most.(2)Association analysis: Bai Zhu,White Peony,Poria and Licorice are closely related to other drugs.(3)Cluster analysis: the first group: psoralen,nutmeg,schisandra,evodia,jujube,cannon ginger,the second group: appendages,dried ginger,wumei,angelica,the third group: banxia,astragalus,Cangzhu,the fourth group: skullcap,huanglian,muxiang,the fifth group: white lentils,yam,coix kernel,sand kernel,ginseng,the sixth group:parsnip,tangerine peel,white peony,white art,poria,citrus shell,chai hu,incense,licorice.Conclusions1.In terms of meta-analysis,in terms of the total effective rate of the outcome indicators,abdominal pain symptom score,the score of abdominal distention symptom and stool frequency score,cure and recurrence,for modern physic group,the TCM group is better,indicating that the traditional Chinese medicine compound can alleviate the abdominal pain and bloating symptoms of patients to a certain extent,effectively reduce the frequency of stool,mdke efficacy higher and recurrence lower.However,due to the traits of TCM and the poor quality of the research methods,the interpretation of the results needs to be cautious,and higher quality literature is needed as evidence support.2.The treatment of IBS-D in TCM is based on strengthening the spleen and removing dampness,focusing on treatment from the spleen,stomach,lungs and liver,timely dispelling evil,often matching dry and wet gas,clearing heat and dispelling wind products,in order to achieve the purpose of attacking and supplementing and treating both symptoms and causes.Clinical multi-purpose and peaceful products,and pay attention to daily care to improve clinical efficacy.