| Objective:1.To investigate the correlation between resting heart rate（RHR）and the severity of coronary artery disease in patients with coronary heart disease（CHD）complicated with hyperuricemia（HUA）.2.To determine the effect of HUA on the relationship between RHR and coronary artery disease in CHD patients.3.To explore the correlation between serum uric acid（SUA）,RHR and the degree of coronary artery among different gender in CHD patients with HUA.Methods:160 patients diagnosed with CHD by coronary angiography in The People’s Hospital of Inner Mongolia Autonomous Region from December 2020 to November2021 were enrolled.CHD patients were divided into CHD+HUA group and CHD control group.RHR was divided into three groups according to three-digit,the low RHR group<70 bpm,the medium RHR group 70-78 bpm,and the high RHR group>78 bpm.Age,gender,history of hypertension,history of diabetes,history of smoking,BMI,LDL-C,HDL-C,SUA,PLT,CRP,FIB and coronary angiography results of all enrolled patients were collected,and Gensini score was performed for all patients.SPSS21.0 software was used for data statistical analysis.Results:1.Comparison of general clinical data between CHD+HUA group and CHD group:BMI,hypertension ratio,RHR,SUA,CRP,number of diseased coronary arteries,Gensini score and rate of three-vessel lesions in CHD+HUA group were significantly higher than those in CHD group,while HDL-C was significantly lower than those in CHD group,with statistical significance（P<0.05）.2.Comparison of Gensini scores among CHD+HUA group,Gensini scores in the high RHR group were significantly higher than those in the medium RHR group and the low RHR group,with statistical significance（P<0.05）;In CHD group,Gensini score of moderate RHR group was significantly higher than that of low RHR group（P<0.05）.3.In CHD+HUA group,female RHR was significantly higher than male RHR（78.95±9.15 vs.73.18±6.66,P<0.01）;There was a significant positive correlation between RHR and Gensini scores in both male and female,and the correlation degree was higher in male（r1=0.665,r2=0.463,P<0.05）.There was no significant difference in RHR and Gensini scores between different genders in CHD group,and no significant correlation between RHR and Gensini scores（P>0.05）.4.Male SUA was significantly higher than female SUA in CHD+HUA group（P<0.05）.For both men and women,SUA in the three-vessel lesion group was significantly higher than that in the no-three-vessel lesion group,but the difference was statistically significant only in women（P<0.05）.Gensini scores were positively correlated with SUA in both men and women,and the correlation was stronger in women（r1=0.608,r2=0.59,P<0.001）.5.In CHD+HUA group,single-factor linear regression analysis showed a significant positive correlation between RHR and SUA and Gensini score（β>0,P<0.05）.Further multiple linear regression analysis showed that RHR and SUA were independent factors affecting Gensini score（β>0,P<0.05）.In THE CHD group,single-factor linear regression analysis showed that RHR,LDL-C,CRP and FIB were significantly positively correlated with Gensini score（β>0,P<0.05）.Further multiple linear regression analysis showed that LDL-C was an independent factor of Gensini score（β>0,P<0.05）.Conclusions:1.RHR of PATIENTS with CHD combined with HUA was faster than that of patients with CHD alone,and the faster RHR was,the more severe the coronary lesions were.2.HUA can enhance the association between RHR and coronary artery lesions in CHD patients,and both SUA and RHR are independent influencing factors of coronary artery lesions in CHD patients with HUA 3.RHR in female patients with CHD complicated with HUA was significantly higher than that in male patients,but the correlation between RHR and the degree of coronary artery disease was greater than that in female patients.4.SUA in CHD patients with HUA was significantly higher in males than in females,but the correlation between SUA in females and the degree of coronary artery disease was greater than that in males. |
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