Study On Microwave Hyperthermia Technology Of With Miniaturized Waveguide Antenna Combined With MOF Material

Cancer is one of the killers that threaten human life and health.Studying the pathogenesis of cancer and exploring how to effectively overcome cancer is a joint research topic of scientific researchers around the world.Traditional cancer treatment methods include surgical treatment,radioactive treatment,chemotherapy,etc.,but the above treatment methods have their own shortcomings.For example,the side effects of surgical treatment are relatively large,the risk of patients is higher Removal and other problems,patients have low selectivity.Although radioactive therapy and chemotherapy can effectively kill the tumor,at the same time,it will also seriously damage normal tissue and cells,and toxic and side effects are relatively large.In order to make up for the shortcomings and deficiencies of traditional therapy,new minimally invasive,efficient,and small-toxic and side effects such as microwave heat therapy are widely used in the field of cancer treatment,which has brought gospel to patients with cancer.Microwave(MW)heat therapy is a new method of treating cancer.It is to use a single antenna or multiple array antennas to gather electromagnetic energy with a wavelength of 300 MHz-300 GHz to the tumor site.MW radiation can cause ions or polar molecules to collide with each other in biological tissues and friction to generate heat.When the internal temperature of biological tissues increases above 42°C,it is enough to cause tumor necrosis.The energy concentration is insufficient.Its MW radiation energy is mainly scattered in the shallow layer,which prevents the heat of the thermal energy to the deep tumor,and makes the deeper tumor cells insufficient heat,which causes the warm zone to survive.In response to this series of issues,this article designed a small-scale waveguide antenna with high energy.A single thermal therapy antenna has met the requirements to be applied to microwave therapy,but because the thermal therapy antenna is not specific in tumor recognition,it is impossible to determine the size of the tumor,the position of the tumor cannot be recognized Control the temperature of the tumor to cause the retention and recurrence of the tumor.In order to solve this problem,this article also explores a method that uses spray-type fast synthetic microwave allergic agents to use the passive targeting effect of allergic agent The antenna,which further locks the tumor position and rapidly heated the tumor area to reduce the damage of normal tissue around the tumor.This work fully combines the advantages of antenna and nanoparticles,providing a new research direction for microwave therapy.The main research content of the paper includes:First,this article designed a 915 MHz miniaturized waveguide antenna.Through the HFSS simulation software optimization,the small-scale waveguide antenna is 6.6 cm~3,achieving the purpose of miniaturization,which can be better applied to the clinic.The simulated echo loss is 25.1d B.The penetration depth of the antenna is relatively stable.The energy can be highly focused and can be quickly heated in a small range.Second,the principle of vacuumization of ultrasonic atomization equipment is prepared by a microwave allergic agent containing Co and Zr elements and named ZCNC.It is verified by experimentally verifying that nanomaterial ZCNC is a good microwave allergy material,and nano-nano The material can be degraded with the micro-loop of the tumor.Based on this,two types of chemotherapy drugs,Apadinib and Demamthon,are naming the AP@ZCNC@PEG@PCM-DEX nano composite material.Load the chemotherapy drug Apatinib(AP)into the empty shell of ZCNC for tumor chemotherapy,and attach temperature control switch to the outer layer of the surface AP@ZCNC.Symeton is adsorbed on the tumor for release,and then the temperature control switch is opened under microwave radiation stimulation to open the internal chemotherapy medicine Apatinib to release the treatment.Third,the microwave allergic agent auxiliary miniaturized waveguide antenna is combined.The antenna has the advantages of small volume,high energy focus,and rapid heating in a small range.And processing,obtained the physical antenna,and at the same time,through body mold experiments,the miniaturization waveguide antenna can achieve rapid heating of the body mold,meet the experimental foundation of tumor microwave therapy,and verify that ZCNC nanomaterials are a good microwave allergic agent The cytotoxicity of ZCNC nanomaterials is verified by cell experiments(when the concentration reaches 200μg/m L,the cell vitality of L929 and H22 is higher than 80%),which can meet the experimental foundation of microwave heat therapy.Finally,EPR,which uses ZCNC nanomaterials,can be enriched on the tumor site to auxiliary miniaturized waveguide therapy antenna for treatment,thereby further locking the tumor position for rapid heating tumor areas to reduce damage to normal tissue around the tumor.ZCNC nanomaterials assist miniaturized waveguide therapy antenna combined therapy,which fully combines the advantages of the two to better prevent and reduce damage to normal cells and greatly improve the treatment effect of cancer.Through experimental verification,animal tumor suppression rates reached 78.01%,15.56%higher than microwave groups.This work shows that the innovative combination of nanoparticles auxiliary miniaturized waveguide antenna has effectively improved the current clinical microwave therapy treatment method,providing a new research direction for microwave co-type therapy.