| Objective:(1)The characteristics of the overall distribution of demographic data,previous history,traditional Chinese medicine(TCM)pattern,examination and laboratory parameters,and clinical treatment regimen of patients with posterior circulation cerebral infarction and lipid metabolism disorders were obtained.(2)Correlations between NIHSS scores at different TG,TC,LDL-C,and HDL-C levels and the muscle strength scores of the upper and lower extremities were obtained.(3)To obtain the effect law of acupuncture integrated therapy intervention on NIHSS scores and the change of muscle strength scores of upper and lower limbs under different levels of TG,TC,LDL-C,and HDL-C.method:(1)The patients with posterior circulation cerebral infarction combined with lipid metabolism disorders who visited the Department of acupuncture clinic of the First Affiliated Hospital of Tianjin University of traditional Chinese medicine from January 1,2015 to December 31,2020 were analyzed as research objects,the patients’ demographic data,previous history,traditional Chinese medicine(TCM)patterns,examination chemical indexes,and clinical treatment regimens were observed,and the overall distribution characteristics of patients with posterior circulation cerebral infarction combined with lipid metabolism disorders were summarized and analyzed.(2)Using the different TG,TC,LDL-C,and HDL-C levels as cut points,the correlation with the NIHSS scores and the muscle strength scores of the upper and lower extremities were analyzed according to the three groups with low medium and high blood lipid levels: 1,2,and3.(3)The levels of different TG,TC,LDL-C and HDL-C were used as cut points to analyze their effect sizes in relation to the changes of NIHSS scores and the muscle strength scores of the upper and lower limbs with acupuncture comprehensive therapy intervention.result:1 basic information distribution characteristics(1)Among 669 patients with posterior circulation cerebral infarction combined with lipid metabolism disorders included in this study,the mean age was 63.4 ± 10.4 years,436(65.2%)were more male than 233(34.8%)female,about 49.9% had smoking history(334cases),and about 43.3% had drinking history(290 cases).In previous history,a history of hypertensive disease was present in up to 75.9%(508 cases),history of coronary atherosclerotic heart disease in 23.8%(159 cases),history of diabetes mellitus in 21.1%(141cases),and history of atrial fibrillation in 6.5%(44 cases).(2)Distribution of TCM syndrome types: about 52.0% of them were Yin deficiency wind activity syndrome(348 cases),about 22.4% were wind phlegm Blocking Collaterals syndrome(150 cases)18.2% were Qi deficiency blood stasis syndrome(122 cases),while the empirical distribution of liver Yang fulminant syndrome and phlegm heat Fu organs was less,respectively,6.3%(42 cases)and 1.0%(7 cases).(3)Examination laboratory results: abnormal liver function was present in about 1.4%(11 patients);Approximately 46.6% had elevated glycated hemoglobin(312 cases);Approximately 17.3% had elevated uric acid(116 cases);About 51.7% had elevated blood homocysteine(346 cases);Shortened thrombin time was present in about 0.4%(3 cases),prolonged thrombin time in about 3.9%(26 cases),and abnormal thrombin time was present in a total of 4.4%(29 cases);A shortened partially activated thrombin time was present in about 24.5%(164 cases),a prolonged thrombin time was present in about 6.1%(41 cases),About 30.6% of them had abnormal time of partial activated thrombin(205 cases);Thrombocytopenia was present in about 1.9%(13 cases),elevated platelets in about 15.7%(105 cases),and a total of about 17.6% had platelet abnormalities(118 cases);Carotid plaques were present in about 51.0%(341 cases);Fatty liver was present in about 35.7%(239 cases).(4)Treatment status: intravenous thrombolysis was administered in 16.1%(108 cases).Lipid regulating drug use: About 72.9% used atorvastatin(488 cases)and about 27.1% used rosuvastatin(181 cases).Anticoagulation and antiplatelet aggregation drug use: rivaroxaban was used in approximately 4.3%(29 cases);About 57.5% used aspirin(385 cases),about27.2% used clopidogrel(182 cases),and about 10.3% combined aspirin and clopidogrel(69cases): about 4.9% did not use antiplatelet aggregation drugs(33 cases).2 Correlation between lipid levels and NIHSS scores and muscle strength of upper and lower limbs(1)There were no statistical differences in the NIHSS scores and the muscle strength scores of the upper and lower limbs among different levels of TC,TG,LDL-C,and HDL-C(all P > 0.05).3 Correlation between blood lipid levels and therapeutic effect of acupuncture combined therapy on NIHSS scores and muscle strength of upper and lower limbs(1)TC:(1)the NIHSS scores of groups 1 and 2 were significantly lower after treatment than before treatment(all P < 0.001),and there was no statistical difference between groups 3before and after treatment in the NIHSS scores(P > 0.05).(2)The NIHSS scores of group 1were lower than those of group 3 after treatment,and the difference was statistically significant(P < 0.05).(3)The muscle strength scores of the upper and lower limbs in the three groups were significantly lower after treatment than before treatment(all P < 0.001).(4)There were no differences in the muscle strength scores of the upper and lower limbs among the three groups after treatment(all P > 0.05).(2)TG: NIHSS scores and the muscle strength scores of the upper and lower limbs in the three groups were significantly lower after treatment than before treatment(all P < 0.001).(2)The NIHSS scores of group 1 were lower than those of group 3 after treatment,and the difference was statistically significant(P < 0.05).(3)There were no differences in the muscle strength scores of the upper and lower limbs among the three groups after treatment(all P >0.05).(3)LDL-C: NIHSS scores and the muscle strength scores of the upper and lower limbs in the three groups were significantly lower after treatment than before treatment(all P < 0.001).(2)The NIHSS scores of group 1 were lower than those of group 3 after treatment,and the difference was statistically significant(P < 0.05).(3)There were no statistical differences in the muscle strength scores of the upper and lower limbs among the three groups after treatment(all P > 0.05).(4)HDL-C: the NIHSS scores of the three groups and the muscle strength scores of the upper and lower limbs were significantly lower after treatment than before treatment(all P <0.001).(2)The NIHSS scores of the 3 groups were lower than those of group 1 after treatment,and the differences were statistically significant(P < 0.05).(3)There were no statistical differences in the muscle strength scores of the upper and lower limbs among the three groups after treatment(all P > 0.05).Conclusions:(1)There was a predominance of male age in patients with posterior circulation cerebral infarction and lipid metabolism disorders,and great majority patients suffer from of hypertension.(2)No correlation existed between the NIHSS score and he upper and lower limbs muscle strength at different levels of TC,TG,LDL-C,and HDL-C.(3)The combination therapy of acupuncture at different TG,LDL-C,and HDL-C levels showed some efficacy in the treatment of NIHSS scores and muscle strength of the upper and lower limbs;TC at the low level(less than 5.2 mmol / L)and middle level((5.2-6.2 mmol / L)The combined therapy of acupuncture at different TC levels showed some efficacy in treating the muscle strength of upper and lower limbs. |
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