Study On The Effect Of Urea Nitrogen On Cardiovascular Adverse Events In Patients With Different Types Of AMI

Objective:By collecting Blood urea nitrogen(BUN)from hospitalized patients with Acute myocardial infarction(AMI),To investigate the influence of BUN on Major adverse cardiovascular events(MACE)in patients with different types of AMI during hospitalization,so as to guide the early clinical identification of AMI high-risk groups and reduce the mortality and disability rate of AMI patients.Methods:This study retrospectively collected 142 patients with AMI patients in Guiyang Second People’s Hospital(Jinyang Hospital)from January 2021 to January 2022,and were collectively diagnosed and hosiptalization with AMI patients,and the patient’s clinical data(age,gender,high Blood pressure and diabetes history,electrocardiogram results,Killip grading)and laboratory indicators(total number of white blood cells,BUN,creatinine,blood glucose,blood lipid).According to whether MACE occurs during the hospital in Hospitals,it is divided into the AMI-MACE group and the AMInon-MACE group,and the electrocardiogram is further divided into ST elevated myocardial infarction(STEMI),Non-St-elevation Myocardial Infarction(NSTEMI),is further divided into STEMI-MACE group and STEMI-non-MACE group,NSTEMI-MACE group,and NSTEMI-non-MACE group.Single factor analysis is performed separately,the logistic regression model is respectively analyzed,and finally draws the subject work characteristic curve(Receiver Operator Chracteristic Curve,ROC Curve)to explore the risk factor during hospitalization in patients with acute myocardial infarction.Further study,the admission BUN has an effect of MACE during hospitalization in patients with different types of acute myocardial infarction.Results:1.Univariate analysis results of AMI showed that age,hypertension,Killip grade,creatinine,urea,white blood cell count and admission hyperglycemia in MACE group were higher than those in non-MACE group,with statistically s ignificant differences(P<0.05).Multivariate logistics analysis results showed tha-t,Age,male,hypertension,Killip grade and urea nitrogen were independent ri sk factors for THE occurrence of MACE during hospitalization.OR value of u rea nitrogen was 1.52(1.10-2.09),indicating that an increase of 1 unit would i ncrease the risk of MACE by 1.52 times.2.Univariate analysis results of STEMI showed that age,hypertension,Kil lip grade,creatinine,urea nitrogen and white blood cell count in MACE group were higher than those in non-MACE group,with statistically significant diffe rences(P<0.05).Multivariate logistics analysis results showed that urea nitroge n was an independent risk factor for MACE during hospitalization.OR value o f urea nitrogen =2.45(1.09-5.52),indicating that an increase of 1 unit would i ncrease the risk of MACE by 2.45 times.3.Univariate analysis of NSTEMI showed that age,Killip grade,urea nitr ogen and hyperglycemia at admission in MACE group were higher than those in non-MACE group,with statistically significant differences(P<0.05).The res ults of multi-factor logistics analysis showed that age,male,hypertension and Killip grade were independent risk factors for MACE during hospitalization(P<0.05,OR>1).4.ROC analysis showed that AUC of urea nitrogen in AMI group,STEM I group and NSTEMI group were the highest,respectively(AUC=0.789,95%C I=0.712 to 0.853),(AUC=0.863,95%CI=0.757 to 0.935),(AUC= 0.726,95%CI=0.611 to 0.822).Conclusions:Age,gender,hypertension,Killip grading and BUN on admission were independent risk factors for MACE in AMI patients.BUN was an independent risk factor for MACE during hospitalization in STEMI patients,but not in NSTEMI patients.Age,gender,hypertension and Killip grade were independent risk factors for MACE in NSTEMI patients during hospitalization.BUN on admission can be used as a predictor of MACE in patients with AMI.