Risk Factors Of Postoperative Intracranial Infection In Patients With Brain Metastasis Of Lung Cancer

Objective: By reviewing the clinical data of patients with brain metastases from lung cancer surgery and to explore the incidence of postoperative in patients with brain metastases from lung cancer risk factors for intracranial infection to occur,thus guide perioperative individualized treatment,reduce the infection rate,reduce the in-hospital time and costs.Methods : A retrospective analysis was conducted on patients diagnosed with lung cancer brain metastasis in neurosurgery of Guilin Medical College Affiliated Hospital and Guilin Nanxishan Hospital from June 2014 to June 2022 who received surgical treatment,Factors including gender,age,BMI,smoking history,history of hypertension,history of diabetes,KPS score,ASA grade,postoperative blood albumin concentration,pathological classification of lung cancer,perioperative hormone useing,neutrophil-lymphocyte ratio,Extubation time and so on were analyzed,to find out the independent risk factors of postoperative intracranial infection in patients with cerebral metastasis of lung cancer,and build nomogram.Results: A total of 132 patients were enrolled,87 males and 45 females,with an average age of 58.88 years,20 cases with postoperative intracranial infection,lung adenocarcinoma was the main pathological type.Intracranial infection occurred in 20 cases.Univariate analysis showed that high ASA grade,posterior cranial fossa surgery,surgical duration≥4 h,perioperative hormone useing,and high preoperative NLR were associated with the occurrence of postoperative intracranial infection.Multivariate analysis showed that posterior fossa surgery,surgical duration ≥ 4 h,perioperative hormone use,and preoperative NLR values were high,These are independent risk factors for postoperative intracranial infection,and the area under the curve(AUC)of the line graph based on multivariate analysis results was 0.911.Conclusions: Univariate analysis results of this study showed that high ASA score,perioperative hormone use,surgical duration≥4 h,posterior cranial fossa surgery and high NLR ratio were risk factors for postoperative intracranial infection in patients with brain metastasis of lung cancer.Multivariate analysis showed that perioperative hormone use,surgical duration≥4 h,posterior fossa surgery and high NLR ratio were independent risk factors for postoperative intracranial infection.The line-map based on multi-factor results has good differentiation and high accuracy,but it needs external data to further verify its validity.