Analysis Of Medication Regularity Of TCM Decoction In Treating Hypothyroidism Based On Data Mining

Research background Hypothyroidism is a systemic hypometabolic syndrome,caused by inadequate thyroid hormone production or weakened thyroid hormone action on account of various reasons.The etiology and pathogenesis of hypothyroidism are intricate.Western medicine does not have effective drugs for the treatment of this disease.The treatment is mainly based on local treatment and symptomatic treatment.However,most western medicines have serious side effects and are prone to relapse after drug withdrawal.The treatment of hypothyroidism in traditional Chinese medicine has positive advantages based on the basis of treatment and syndrome variation.it can also alleviate the toxic and side effects While treating the disease,which may be caused by the use of western medicine.in terms of hypothyroidism,Traditional Chinese medicine has a long history.and its related treatment experience has been passed down from generation to generation.The traditional Chinese medicine treatment of hypothyroidism is also constantly innovating in the inheritance.However,there is currently no systematic experience on the treatment of hypothyroidism with traditional Chinese medicine.literature analysis.Summarizing and summarizing the development and current situation of TCM treatment of hypothyroidism,understanding its development and current situation is of great significance for the future development and innovation of TCM treatment of hypothyroidism.Therefore,this subject screened the clinical observation literature to summarize the frequency and regularity of drugs on the treatment of hypothyroidism with traditional Chinese medicine in the past 10 years,which can provide clinical and scientific research reference for the treatment of hypothyroidism with Chinese medicine in the future and provide reference for the clinical treatment of hypothyroidism.Research purpose This paper aims to conduct data mining with and the prescriptions etc,in the literature that meet the inclusion criteria through the clinical observation literature of hypothyroidism’s treatment with traditional Chinese medicine in the past ten years(2012-2021)to summarize the medication rules of traditional Chinese medicine for the treatment of hypothyroidism,which can provide a reference for the treatment of hypothyroidism with traditional Chinese medicine.Research methods Relevant literature searches were conducted on the Chinese National Knowledge Infrastructure(CNKI)and PubMed databases for the treatment of hypothyroidism with traditional Chinese medicine.The literatures that met the inclusion criteria were screened out by reading,and the contents of the literature(document publication time,journals,core authors,TCM syndrome types,treatment methods,courses of treatment,number of cases,etc.)were sorted out by EXCEL.Through data mining software,association rules,cluster analysis and other methods are used to mine the frequency and regularity of drugs in the treatment of hypothyroidism with traditional Chinese medicine.Research results The main types of patients with hypothyroidism included kidney-yang deficiency type(78.43%)and spleen-yang deficiency type(54.90%),followed by spleen-yang deficiency type(29.41%),blood stasis type(11.76%),etc.;frequency of use The top 6 herbs were astragalus(76.47%),Poria(62.75%),Atractylodes(60.78%),Angelica(56.86%),Chinese yam(54.90%)and Rehmannia glutinosa(52.94%).The main effect of the traditional Chinese medicine used is tonic for deficiency,and the respective proportions are for qi(49.16%),yang(24.41%),blood(21.40%),and yin(5.02%).Association rule analysis was performed on high-frequency traditional Chinese medicines with frequency ≥15 times.As a result,33 rules were generated,and the association rules of TCM pairs and TCM groups were extracted.Among them,there were 7 pairs of medicines,17 of the 3-medicine groups,and 9 of the 4-medicine groups.Cluster analysis of traditional Chinese medicines was carried out,and three potential new Chinese medicine prescriptions were obtained,namely C1:cinnamon,dodder,aconite,dogwood,rehmannia glutinosa,yam,wolfberry,antler gum,eucommia,astragalus,angelica,and Alisma;C2:Chuanxiong,Salvia,dried ginger,Prunella vulgaris,tangerine peel;C3:Atractyl odes,licorice,Poria,Codonopsis,Paeonia lactiflora,Epimedium,Cistanche.Research conclusionThrough data mining of 51 literatures,it is found that traditional Chinese medicine(TCM)is mainly used to treat hypothyroidism,especially for invigorating Qi and Yang.Three potential new TCM prescriptions can be applied to different syndrome types of hypothyroidism through appropriate drugs addition and subtraction.The compatibility of the three potential new prescriptions reflects the three main directions in the treatment of hypothyroidism,namely,warming Yang,promoting blood circulation and removing stasis,and invigorating Qi.The compatibility of specific prescriptions can also be combined with other therapeutic methods,with the emphasis on treating the root of the disease,treating both symptoms and symptoms.