Analysis Of Risk Factors For Adverse Outcomes After Intracranial Meningioma Surgery

Objective:To explore and analyze the associated risk factors on adverse outcomes after intracranial meningioma surgery,including m FI-5 and tumor factors,for better perioperative management of patientsMethods:In this retrospective study,patients were collected who were pathologically diagnosed with meningioma and hospitalized in the Department of Neurosurgery of Shanxi Provincial People’s Hospital from June 2016 to June 2021.Firstly,recording the main risk factors and other risk factors of the patients.The main risk factors : m FI-5and tumor factors(tumor location,tumor size,WHO grade),other risk factors : age,smoking status,drinking status,Body Mass Index(BMI).Then,the postoperative adverse outcomes of these patients were recorded: 30-day readmission 30-day mortality,reoperation,Discharged not to home,endotracheal intubation was continued 24 hours after surgery and(hospital length of stay [LOS],and medical and surgical complications.Finally,SPSS 22.0 was used for statistical analysis.The quantitative data were described by Median and upper and lower quartiles instead of normal distribution,and the two groups were compared by Mannwhitney U test.Chi-square test was used for the comparison among the unordered classification data groups.The correct chi-square was used when the theoretical frequency was more than 1 and less than 5,and Fisher exact probability was used when the theoretical frequency was less than 1.Linear regression and binary Logistic regression were used in multivariate analysis.P < 0.05 indicated that there was statistical difference.Results:We analyzed a cohort of 333 patients who underwent elective craniotomy for intracranial meningioma surgery.193 cases(58.0%)were no-frailty,103 cases(30.9%)were low-frailty,and 37 cases(11.1%)were medium-to-high frailty.The results of multivariate analysis are summarized in Table 4 and 5.When adjusting for other covariates,we found statistically-significant associations between medical complications.,and both low(adjusted OR1.746)and medium-to-high m FI-5 scores(adjusted OR 5.833),.A similar,statistically-significant association was found for LOS(adjusted OR 2.563 and 4.077).medium-to-high m FI-5 scores were associated with endotracheal intubation was continued 24 hours after surgery increased risks of(adjusted OR 2.873)and medical complications(adjusted OR 5.833)but not of 30-day readmission,.30-day mortality,reoperation.Increased Tumor size was an independent risk factor for worse clinical outcomes after meningioma resection,including increased LOS(P<0.05),discharge to a higher level of care(P < 0.05),.The location of the tumor is associated with substantially increased odds of medical complications and LOS(P<0.05).Conclusion:1.Increased BMI and age were independent risk factor for worse clinical outcomes after meningioma resection.2.Pre-operative frailty,as determined by m FI-5,is associated with substantially increased odds of medical and surgical complications,discharge to a destination other than home,endotracheal intubation was continued 24 hours after surgery,and LOS.3.Increased Tumor size was an independent risk factor for worse clinical outcomes after meningioma resection,including increased LOS,discharge to a higher level of care.The location of the tumor is associated with substantially increased odds of medical complications and LOS.