The Correlation Study Of Preoperative Endogenous Opioid Peptides,pain Sensitivity And Intraoperative Remifentanil Consumption In Patients With General Anesthesia

Objective:To explore the correlation of perioperative pain sensitivity,endogenous opioid peptide changes and intraoperative remifentanyil consumption in orthopedic lumbar surgery patients with general anesthesia.Methods:Seventy two patients undergoing PLIF with intravenous general anesthesia were selected.3ml of blood from the non-infusion side elbow vein was collected before anesthesia(T1)and 30 min after anesthesia recovery(T2).The serum levels ofβ-EP,LEK and DYN were measured by ELISA.The thermal pain threshold,thermal pain tolerance threshold,ischemic pain threshold,ischemic pain tolerance threshold and mechanical pain threshold was measured by QST respectively before anesthesia(T1)and 24 hours after operation(T3).The consumption of remifentanil during anesthesia was recorded.Results:Compared with T1,the level of serumβ-EP,LEK,DYN decreased significantly at T2(P<0.05,P<0.001,P<0.001);Compared with T1,the thermal pain threshold,ischemic pain threshold,mechanical pain threshold,thermal pain tolerance threshold and ischemic pain tolerance threshold were significantly reduced at T3(P<0.001).Preoperative ischemic pain threshold and mechanical pain threshold were positively associated with serum β-EP and LEK;the intraoperative remifentanyl consumption was significantly positively associated with preoperative serum β-EP levels.Conclusion:Postoperative serum β-EP,LEK,DYN and pain thresholds were significantly decreased in lumbar surgery patients with general anesthesia;patient ischemic pain threshold and mechanical pain threshold were significantly associated with preoperative serum β-EP and LEK.Moreover,there was a significant positive correlation between intraoperative remifentanyl consumption and preoperative serumβ-EP.