Network Meta-analysis Of Anti-inflammatory Effects Of Statins

Objective:Statins have many effects,such as anti-inflammatory,improving endothelial function,antioxidation,antithrombosis and so on.Their anti-inflammatory effects have become the focus of research.This study was to evaluate the anti-inflammatory effect of different statins by network meta-analysis.Methods:The database of EMBase,PubMed and Cochrane Library were searched by computer,and randomized controlled trial(RCTs)with statin as the intervention measure up to 2021-05-31 and outcome index involving changes of inflammatory cytokines was collected.Literatures were screened,extracted,and evaluated independently by two researchers,and then network meta-analysis was performed using Stata 15.1 software.Results:A total of 59 RCTs were collected,including 5193 subjects,involving 6 kinds of statins.The results showed that:The effects of statins on reducing CRP were ranked as follows,pitavastatin(79.3%)> rosuvastatin(75.0%)> atorvastatin(66.2%)> pravastatin(48.2%)>fluvastatin(42.5%)> simvastatin(29.0%)> placebo(9.8%).The effects of statins on reducing hs CRP were ranked as follows,rosuvastatin(83.1%)> simvastatin(75.6%)>pitavastatin(64.5%)> atorvastatin(42.7%)> fluvastatin(28.1%)> placebo(6.0%).The effects of statins on reducing IL-6 were ranked as follows,rosuvastatin(99.1%)>simvastatin(50.6%)> atorvastatin(49.5%)> pravastatin(42.0%)> placebo(8.8%).The effects of statins on reducing TNF – α were ranked as follows,pitavastatin(77.1%)>rosuvastatin(76.1%)> simvastatin(66.2%)> atorvastatin(59.8%)> fluvastatin(42.9%)>pravastatin(14.3%)> placebo(13.7%).Conclusion:Pitavastatin has the strongest effect on reducing CRP and TNF-α,followed by rosuvastatin;rosuvastatin has the strongest effect on reducing hs CRP and IL-6,and simvastatin takes the second place.The results of this study still need to be verified by highquality studies due to the limited number and sample size of included studies.