Clinical Analysis Of Mortality Related Factors In Reoperation Of Anastomotic Leakage After Radical Resection Of Rectal Cancer

Objective:Anstomotic leakage is one of the most common serious complications after radical resection of rectal cancer.reoperation is the last choice of emergency treatment and has a high mortality.The aim of this study was to investigate the risk factors,prevention and treatment of reoperation of Anastomotic leakage(AL)after radical resection of rectal cancer.Methods:This study included 94 patients with anastomotic leakage reoperation after radical resection of rectal cancer in the Second Affiliated Hospital of Nanchang University from August 2011 to June 2021.General Clinical Data and surgical related factors were collected.SPSS26.0 software was used to analyze the related data,analyze the correlation between the related clinical factors and the death of anastomotic leakage reoperation,and get the related risk factors and independent risk factors of the death of anastomotic leakage reoperation after radical resection of rectal cancer.Results:The study included 94 patients who met the screening criteria.23 patients(24.5%)died of anastomotic leakage reoperation,including 12 males(21.1%)and 11females(29.7%).(1)Univariate analysis showed that age,ASA grading,interval of reoperation,acute renal injury,septic shock were correlated with reoperation death(p < 0.05);(2)Multivariate logistic regression analysis showed that age(OR = 4.970,p =0.016),time between reoperation(OR = 3.300,p = 0.047),septic shock(OR = 3.465,p = 0.038)were the independent risk factors of mortality in patients with anastomotic leakage reoperation(p < 0.05).Conclusion:(1)Age,ASA grading,interval between reoperations,acute renal injury and septic shock were significantly associated with mortality after reoperation for anastomotic leakage of rectal Cancer(p < 0.05);(2)Age,interval of reoperation and septic shock were independent risk factors for mortality in patients with anastomotic leakage(p < 0.05).(3)For patients with older age,shock,acute renal injury,and ASA Grade IV,the second operation should be carried out early,which can reduce the death of reoperation.