Comparison Of Tumor Characteristics And Prognosis Between Early-onset And Non-early-onset HCC

Purpose:The differences in basic characteristics and tumor characteristics were compared between patients with early and non-early HCC,and the prognosis differences between the two groups were analyzed.Method:Patients with primary treated liver cancer undergoing liver resection in the Second Affiliated Hospital of Nanchang University were retrospectively analyzed.According to the definition of early-onset liver cancer by the American Commission of Liver Disease,male liver cancer patients below 40 and female liver cancer patients below 50 were included in the early-onset liver cancer group,and other liver cancer patients were included in the non-early-onset liver cancer group.Finally,101 patients were included in the early-onset liver cancer group and105 patients in the non-early-onset liver cancer group.Using the chi-square test to compare the two groups of basic characteristics,logistics regression analysis was used to find risk factors for MVI,Kaplan-Meier method for survival and recurrence risk,and the Cox proportional hazards model predicted risk factors affecting prognosis.The propensity score matching method(PSM)was used to balance the variables with unbalanced basic data between the two groups and obtain matched patients.Finally,the survival and recurrence risk were analyzed again for the successfully matched patients.Results:1.Smoking in patients with early-onset liver cancer,AFP positive,A decreased albumin(albumin <3.5g / L),tumor size,surgical mode,microvascular invasion(MVI),postoperative prophylactic TACE treatment,and postoperative chemoradiotherapy showed statistically significant differences(P <0.05).However,sex,family history,ALT elevation(ALT 80 IU / ml),HBV-DNA quantification,differentiation degree,liver cirrhosis,and tumor site were not significantly different between the two groups.2.logistics regression analysis suggested that early-onset liver cancer group,tumor diameter> 3cm,low differentiation,and T4 stage were independent risk factors for MVI detection.3.Cox regression analysis showed that albumin content was higher than 3.5g/ L,and postoperative prophylactic TACE treatment was an independent protective risk factor affecting prognosis.Before PSM,the 1-year,3-year,and 5-year postoperative survival rates in the early-onset HCC group were 85.1%,73.2%,and67.3%,respectively.However,the 1-year,3-year and 5-year survival rates of the nonearly-onset liver cancer group were 84.8%,69.5% and 61.0%,respectively.There was no significant difference(0.587).The 1-year,3-year and 5-year survival after PSM was 80.0%,66.1%,and 61 and 5-year,96.9%,80.0% and 72.3%,respectively(p=0.047).Conclusion:1.Patients with early-onset liver cancer are more likely to develop MVI than patients with non-early-onset HCC.2.Patients with early-onset liver cancer had a higher risk of recurrence than the non-early-onset liver cancer group and a worse prognosis.