| Objective:To explore the clinical efficacy of Professor Liu Zhongyong’s intervention on patients after percutaneous coronary intervention(PCI)by using the empirical formula Yiqi Huoxue Tongmai granule,evaluate its safety and clinical effect through quantitative indicators,and summarize the clinical experience and academic thought of the tutor,so as to better provide guidance for the clinical medication plan after PCI,At the same time,it also provides new ideas and methods for traditional Chinese medicine to intervene after PCI.Method:60 patients who met the inclusion and exclusion criteria were randomly divided into control group and treatment group.30 patients in the control group were given aspirin enteric coated tablets 100 mg once a day and taken on an empty stomach in the morning;Clopidogrel bisulfate tablets 75 mg,once a day,before going to bed;Atorvastatin calcium tablets 20 mg,once a day,before going to bed;ACEI / ARB drugs β Receptor blockers should also be used if there are no contraindications;If patients have other basic diseases such as hypertension and diabetes,appropriate drugs should be selected according to the specific conditions of patients to control blood pressure and blood sugar.In addition,in order to avoid gastrointestinal adverse reactions caused by long-term use of antiplatelet drugs after operation,PPI drugs are often used in combination in the early stage.30 cases in the treatment group were treated with Yiqi Huoxue Tongmai Granule on this basis;Both groups were treated for 2 courses(one course was four weeks).The TCM symptom score,angina pectoris degree,ECG,creatine kinase isoenzyme(CK-MB),cardiac troponin I(c Tn I),platelet maximum aggregation rate and other indexes of the two groups before and after treatment were recorded and statistically analyzed.Result:1.Comparison of curative effect of TCM symptoms: the total effective rates of the treatment group and the control group were96.7% and 83.3% respectively.The TCM symptoms of the two groups were improved after treatment.After statistical analysis,the treatment group was better than the control group in improving TCM symptoms(P<0.05).2.Comparison of curative effect of TCM symptoms: after treatment,the primary and secondary symptoms of the two groups were improved.By comparing the total score of TCM symptoms and the score of each single symptom between the two groups after treatment,and through statistical analysis,the treatment group was better than the control group in improving the primary and secondary symptoms(P<0.05).3.Comparison of curative effect of angina pectoris degree: after treatment,the symptoms of angina pectoris in the two groups were improved.The total effective rates of the control group and the treatment group were 63.3% and 90.0% respectively.Through statistical analysis,the treatment group was better than the control group in improving the degree of angina pectoris(P<0.05).4.Comparison of ECG efficacy: After treatment,the ECG curative effect of the two groups was improved.The total effective rate of the control group was 60.0% and that of the treatment group was 86.7%.Through statistical analysis,the treatment group was better than the control group(P< 0.05).5.Comparison of the curative effects of CK-MB and c Tn I: after treatment,the values of CK-MB and c Tn I in the two groups were improved,and the values of the two groups were statistically analyzed.The value of CK-MB was tested by independent sample t-test,and the value of c Tn I was tested by rank sum test.The results showed that the P values were less than 0.05,indicating that the treatment group was better than the control group.6.Comparison of the curative effect of platelet maximum aggregation rate: after treatment,the values of ADP and AA platelet maximum aggregation rate fluctuated within the normal range,and the values after treatment were compared between the two groups.The results showed that the P values were greater than 0.05,indicating that there was no significant difference in the improvement of curative effect between the two groupsConclusion:1.Yiqi Huoxue Tongmai granule has a good intervention effect on patients with coronary heart disease after PCI.It can effectively improve the symptoms of traditional Chinese medicine,angina pectoris and myocardial injury,and improve the quality of life of patients.2.During the treatment with Yiqi Huoxue Tongmai granule,the safety indexes of patients were not abnormal,indicating that the intervention of Yiqi Huoxue Tongmai Granule on patients after PCI is not only effective,but also safe and reliable,which can provide new ideas for clinical intervention after PCI. |
PDF Full Text Request