| Objective:Through retrospective analysis and prospective observation on the treatment of chronic stable angina pectoris(blood stasis syndrome)with Guanxinning Tablets,the clinical efficacy and safety of Guanxinning Tablets in the treatment of this disease were understood.According to the theory of blood stasis syndrome and blood vessels in traditional Chinese medicine,and comparing blood lipids,rheology,cardiac function,ET-1,NO,PAI-1,t PA and other indicators before and after treatment,it is more conducive to the objectification and standardization of blood stasis syndrome differentiation,to further guide clinical treatment.Methods:A total of 240 patients with chronic stable angina pectoris(blood stasis syndrome)who were admitted to our hospital from September 2018 to December 2020 were selected for retrospective analysis,and their blood lipids,rheology,cardiac function,CCS classification,blood routine,liver and kidney function for statistical analysis.Then through a prospective observation of 60 patients with chronic stable angina pectoris(blood stasis syndrome)who were hospitalized in our hospital from January 2021 to October 2021,their ET-1,NO,PAI-1,t PA,angina pectoris Symptom scores,TCM syndrome scores,Seattle Angina Scale scores,comprehensive clinical efficacy and safety indicators were statistically analyzed.SPSS25.0 statistical software was used for analysis,in which the retrospective analysis used the propensity score matching method,the matching used the adjacent 1:1 matching,and the caliper value was 0.03.Results:1.Blood lipid index: In retrospective analysis,there were significant differences in the overall level of blood lipid between the two groups before and after treatment(P<0.01).After treatment,there were significant differences in TC,TG,HDL-C between the two groups(P<0.01),and in LDL-C,the difference was statistically significant(P<0.05).2.Hemorheology indexes: In retrospective analysis,there were significant differences in the overall level of rheology between the two groups before and after treatment(P<0.01).After treatment,there were significant differences in plasma viscosity and whole blood viscosity high shear group between the two groups(P<0.01),and there were significant differences in whole blood viscosity low shear and fibrinogen content between the two groups(P<0.05).3.Cardiac function index: In retrospective analysis,there were significant differences in the overall level of cardiac function between the two groups before and after treatment(P<0.01).After treatment,there were significant differences in LVEF and LVESD between the two groups(P<0.01),and in terms of LVEDD,the differences between the two groups were statistically significant(P<0.05).4.CCS grading index: In retrospective analysis,the number of grade I cases in the observation group increased significantly after treatment,and its proportion exceeded that of the control group;the number of grade II cases in the control group exceeded the observation group,and the proportion was higher than that in the observation group.5.Serum ET-1,NO,PAI-1,t PA: In the prospective observation,the serum ET-1,NO,PAI-1,t PA contents of patients before and after treatment were significantly different(P<0.01).After treatment,there were significant differences in the overall levels of serum ET-1and NO levels between the two groups(P<0.01).There were statistically significant differences in the overall levels of serum PAI-1 and t PA between the two groups(P<0.05).6.Angina pectoris symptom score: In the prospective observation,there were significant differences in the angina symptom scores and total scores between the two groups before and after treatment(P<0.01).After treatment,compared with the control group,the pain degree score and total score were significantly different between the observation group and the control group(P<0.01).7.TCM syndrome scores of angina pectoris: In the prospective observation,the scores of TCM syndromes and total scores of patients with angina pectoris were significantly different before and after treatment in the group(P<0.01).After treatment,compared with the observation group,the scores of chest pain and chest tightness of the main symptoms,the score of shortness of breath of the secondary symptoms,and the total score of syndromes were significantly different(P<0.01),and the scores of palpitations,fatigue,and dark purple complexion were different between the groups.There was statistical significance(P<0.05).8.Seattle Angina Pectoris Scale Score: In the prospective observation,the Seattle Angina Pectoris Scale score was significantly different before and after treatment within the group(P<0.01).After treatment,compared with the control group,the angina pectoris stable state score between the observation group and the control group was significantly different(P<0.01),and there were significant differences in the scores of physical activity limitation,angina attack,treatment satisfaction,and disease awareness between the groups(P<0.05).9.Comprehensive clinical efficacy: in the prospective observation,the total effective rate of the observation group was 86.67%;the total effective rate of the control group was 70.00%.The nonparametric rank sum test showed that there was a significant difference in curative effect between the two groups(P<0.05).Conclusion:(1)Guanxinning Tablets can significantly improve the clinical efficacy of patients with chronic stable angina(blood stasis syndrome),not only can improve blood lipids,rheology,cardiac function,angina attacks,TCM symptoms and quality of life,but also can improve Reduce the production of ET-1,promote the increase of NO,reduce PAI-1,and increase t PA.(2)Through the analysis of blood lipids,rheology,cardiac function,ET-1,NO,PAI-1,t PA and other indicators,it is found that these laboratory test indicators are of great significance for the diagnosis of coronary heart disease with blood stasis syndrome,and can be used to judge the curative effect and prognosis.(3)Drug safety: No abnormal indicators in blood routine,liver function and renal function and adverse reactions of patients with medication were found,indicating that Guanxinning Tablet is safe and reliable. |
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