Visible-Light-Induced Synthesis Of C3-Alkylated Quinoxalinones

Quinoxalin-2(1H)-one is a kind of nitrogen-containing heterocyclic compound skeleton with important application merit,and the C3 derivatives of this kind of compounds exhibit important biological and pharmacological activities.The synthesis of such derivatives has been paid intense attention by medicinal chemists and organic chemists for a long time.As a green and efficient synthetic strategy,visible light-induced redox catalysis is one of the frontier research fields and important research topics in organic synthesis,and it has become an ideal tool for green manufacturing of current drugs.In this dissertation,the direct alkyl modification of the C3-H bond of quinoxalinone has been aimed as research goal,and the visible light-induced C3 diversity alkylation of quinoxalinone has been achieved.Simple and readily available alkanes,N-alkyl substituted amides,alcohols are used as alkylating reagents in this reaction.Compared with traditional methods,this reaction has the following characteristics: mild reaction conditions,simple operation,readily available substrate sources,wide substrate applicability,environmental friendliness,and no transition metals involved.Preliminary mechanistic studies suggest that the reaction undergoes a free radical pathway.It lays a good foundation for further biological activity research of this kind of compounds.