Effect Of Panax Notoginseng On Prognosis And Mechanism Of Ultra-early Intravenous Thrombolysis In Patients With Cerebral Infarction

Objective:Treated with Chinese herbal medicine notoginseng in super early intravenous thrombolysis in patients with cerebral infarction and to explore its effect on the prognosis of patients and mechanism research,new diagnosis and treatment for the Chinese medicine treatment of cerebral infarction patients.Methods:A total of 70 patients with ultra-early intravenous thrombolysis with cerebral infarction who received inpatient treatment in department of Neurology,Qingdao Hospital of Traditional Chinese Medicine were selected.Among them,66 cases met the criteria of diagnosis,inclusion and exclusion,and were divided into control group and observation group according to the method of randomized controlled trial,33 cases in each group.Both groups received conventional treatment,and the observation group received panax notoginseng intervention on this basis.According to the levels of molecular biological indicators of metal matrix protease(MMP-9)and vascular endothelial growth factor(VEGF),the scores of the National Institutes of Health Stroke Scale(NIHSS scale),m RS Prognosis Scale and GRASPS Scale,Results of imaging examinations(cranial CT and MRI,etc.)were evaluated and compared between the two groups before treatment,14 days after treatment,and 3 months after treatment.SPSS 20.0 statistical software was used for statistical analysis of the data.Results:1.Two groups of patients before treatment the observation indexes no statistical difference(p > 0.05).2.14 days after treatment,observation group molecular biology index(MMP-9,VEGF)expression levels are lower than the control group,with statistically significant differences(p < 0.01);The scores of NIHSS scale and GRASPS Scale in the observation group were lower than those in the control group,with significant statistical differences(P < 0.01).Observation group"m RS prognosis assessment score of 0 ～ 2 points more than the control group,the number of statistically difference(p < 0.05);Imaging examination results cerebral hemorrhage fewer than the control group,with statistical difference(p < 0.05).3.3 months after treatment,the observation group the NIHSS scale score lower than the control group,with statistically significant difference(p< 0.01);"MRS prognosis assessment score of 0 to 2 points more than the number of the control group,with statistical difference(p < 0.05);Two groups of imaging examination results no statistical difference(p > 0.05).Conclusion:1.The treatment of intravenous thrombolysis patients with cerebral infarction can reduce the incidence of cerebral hemorrhage after thrombolysis,improve the clinical symptoms of patients,and have a positive effect on the prognosis of patients.2.The mechanism of action of Panax notoginseng on intravenous thrombolytic patients is to reduce the expression level of molecular biological indicators(VEGF,MMP-9)in patients,thereby reducing the incidence of cerebral hemorrhage.