| Objective:This study through the analysis of systemic lupus erythematosus clinical features between different syndrome types and blood lipids index,homocysteine and other laboratory index differences,explore two correlation,for systemic lupus erythematosus of traditional Chinese medicine in the search for a more objective clinical evidence,for the overall adjustment of TCM of systemic lupus erythematosus.Methods : A total of 160 patients with systemic lupus erythematosus who were hospitalized in the rheumatology department of Qianfoshan Hospital and Shandong Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were collected.The data of four diagnoses were obtained by observation,smell,inquiry and cutting,and the TCM syndrome types were identified.The general clinical data and laboratory indicators were recorded.The database including syndrome type,clinical data and laboratory index was constructed,and the indexes of TCM syndrome type and database were analyzed by statistical software.Results:1.The gender ratio of 160 patients with systemic lupus erythematosus was about 1:6.There was no statistical difference in gender of 7 TCM syndrome types(P>0.05),but there were statistical differences in age and disease course of each syndrome type(P<0.05).2.The median of triglyceride(TG)and total cholesterol(TC)in spleen-kidney-Yang deficiency syndrome was the highest,and there were statistical differences compared with stasis heat-obstruction syndrome,fever-toxic syndrome,rheumatism heat-obstruction syndrome,Yin deficiency internal heat syndrome and liver-kidney-yin deficiency syndrome(P<0.05).The low density lipoprotein cholesterol(LDL-C)in spleen and kidney Yang deficiency syndrome was also the highest,and there was statistical difference between Yin deficiency internal heat syndrome and heat toxic fever syndrome(P<0.05).The high density lipoprotein cholesterol(HDL-C)in spleen-kidney Yang deficiency syndrome was the lowest,and there were statistical differences with Yin deficiency internal heat syndrome and liver-kidney Yin deficiency syndrome(P<0.05).3.The median of serum homocysteine(Hcy)was the highest in the fever syndrome(15.75)and the lowest in the qi and blood deficiency syndrome(11.5),and there was a statistical difference between them(P<0.05).4.The C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)of heat toxin syndrome were the highest,which were statistically different from those of qi and blood deficiency syndrome,Yin deficiency and internal heat syndrome,liver-kidney Yin deficiency syndrome and spleen-kidney Yang deficiency syndrome(P<0.05).CRP of heat toxin syndrome was also statistically different from rheumatic heat bi syndrome(P<0.05).There was statistical difference between ESR and heat obstruction syndrome(P<0.05).The median complement C3 and C4 of spleen-kidney-Yang deficiency syndrome were the smallest,and there were statistical differences with liver-kidney-yin deficiency syndrome,fever-toxic fever syndrome,rheumatic heat bi syndrome and Yin deficiency internal heat syndrome(P<0.05),respectively.The WBC and Hb of spleen-kidney-Yang deficiency syndrome were the smallest.In WBC,There were statistically significant differences between qi and blood deficiency syndrome and liver and kidney Yin deficiency syndrome(P<0.05).In Hb,there were statistical differences between Hb and heat fever syndrome,rheumatic heat bi syndrome,Yin deficiency internal heat syndrome,liver and kidney Yin deficiency syndrome,and stasis heat bi syndrome(P<0.05).5.There were statistically significant differences in the disease activity of the 7 TCM syndromes(P<0.05).The overall activity of the patients with fever fever syndrome was heavier,and there were statistically significant differences with Yin deficiency internal heat syndrome and spleen and kidney Yang deficiency syndrome respectively(P<0.05).There were statistically significant differences between qi and blood deficiency syndrome and stasis and heat and obstruction syndrome,rheumatic heat and obstruction syndrome and heat and toxin incandescence syndrome(P<0.05),and there were statistically significant differences between liver and kidney Yin deficiency syndrome and rheumatic heat and toxin incandescence syndrome(P<0.05).6.The level of Hcy in patients with cardiovascular involvement(18.72±16.92)was significantly higher than that in patients without cardiovascular involvement(12.87±5.23).There was a positive correlation between Hcy and activity(P<0.05),but no correlation between Hcy and other physical and chemical indicators(P>0.05).TG was positively correlated with TC and LDL-C(P<0.05),but negatively correlated with HDL-C,C3 and C4(P<0.05).TC was positively correlated with LDL-C(P<0.05),but negatively correlated with C3(P<0.05).Hdl-c was positively correlated with LDL-C and C3(P<0.05).C3 and C4,CRP and ESR were positively correlated(P<0.05).Conclusion:1.SLE mostly occurs in women of childbearing age between 20 and 40 years old.Among the 7 syndrome types,the median age,median course and median activity of feverish fever syndrome are the smallest,shortest and highest.The age of liver and kidney Yin deficiency syndrome was the longest,and the activity of qi and blood deficiency syndrome was the lowest.2.Among the 7 TCM syndrome types,the median TG,TC and LDL-C of spleen and kidney Yang deficiency syndrome was the largest,while hd L-C,C3,C4,WBC and Hb were the smallest.The Hcy,CRP and ESR of heat poisoning syndrome were the highest,while the Hcy of qi and blood deficiency syndrome was the lowest.After statistical analysis,there were statistical differences among some syndrome types,which could be used as a reference index for TCM syndrome differentiation and treatment.3.The higher Hcy in SLE patients,the higher degree of disease activity,and the more serious cardiovascular involvement;The higher TG was,the higher TC and LDL-C,and the lower HDL-C,C3 and C4 were.The higher TC was,the higher LDL-C was and the lower C3 was.The higher HDL-C was,the higher LDL-C and C3 were.C3 and C4,CRP and ESR were positively correlated. |
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