Objective: To explore the correlation of repetitive transcranial magnetic stimulation(rTMS)in improving neurological function and recovery of serum inflammatory factor IL-6 in patients with post-stroke neurogenic bladder(PSNB),which provides a reference for clinical rTMS to improve urinary function,and promote the recovery of nerve function.Methods: A total of 60 patients with acute ischemic PSNB who visited the Affiliated Hospital of Yanbian University from August 2021 to February 2022 and met the inclusion criteria were selected,and the enrolled study subjects were divided into a control group and an rTMS group according to the random number method,with 30 cases in each group.The control group was given conventional treatment of antithrombotic,circulation improvement and nerve nutrition;the rTMS group was treated with the transcranial magnetic stimulation system Rapid2 on the basis of conventional drug therapy,with a stimulation frequency of 5Hz,2000 times,at an interval of 0.5s,and a treatment time of 10 min per day,with 14 days set as a treatment cycle.Peripheral blood was collected on the day of admission and the next morning of the 14 th day of treatment,and the serum IL-6 level was measured by ELISA,The differences in National Institute of Health stroke scale(NIHSS)and Overactive bladder symptom score(OABSS)scores were compared before and after treatment.Result:(1)Comparison of NIHSS scores: there was no statistical difference between the two groups before treatment(P > 0.05),and the NIHSS scores decreased in each group after continuous stimulation with 5 Hz rTMS,and the comparison of scores before and after treatment was statistically different(P < 0.05);the comparison between the rTMS group and the control group after treatment was statistically different(P < 0.05).(2)Comparison of OABSS scores:there was no statistical difference between the two groups before treatment(P>0.05),and OABSS scores decreased in both groups after 5 Hz rTMS continuous stimulation,and the comparison of scores before and after treatment was statistically different(P<0.05);after treatment,the OABSS scores in the rTMS group were significantly lower than those in the control group,which was statistically different(P<0.05).(3)Changes in serum IL-6 levels: there was no statistical difference between the two groups before treatment(P > 0.05),and after 14 consecutive days of treatment,the IL-6 detection values in the two groups were significantly lower than those before treatment,with statistical differences(P < 0.05);after treatment,the IL-6 detection values in the rTMS group were significantly lower than those in the control group,with statistical differences(P < 0.05).(4)Comparison of clinical efficacy: 3 cases were effective in the control group and 13 cases were effective in the rTMS group after the two groups underwent treatment.The total effective rate of the rTMS group was higher than that of the control group,with statistical differences(P <0.05).Conclusion:(1)rTMS treatment can improve urinary function and promote neurological recovery in patients with acute ischemic PSNB,and the effect is better than conventional treatment.(2)rTMS treatment can effectively reduce the expression level of IL-6in the serum of PSNB patients,suggesting that the intervention effect of rTMS may be related to the inhibition of inflammatory response in vivo.(3)New ideas for clinical treatment of PSNB are provided by the results of this study. |