| Background:Hypertension is the single largest cause of global disease burden and global mortality,and it is also one of the major public health problems in China.The rate of awareness,treatment and control of hypertension in Chinese are at a low level,it is suggested that the correct and effective treatment of hypertension requires both drug and non-drug interventions,and non-drug interventions should be accompanied by each stage of the development of hypertension.Attention should also be paid to the effect of lifestyle and environmental factors on the formation of hypertension-related risk factors in the course of treatment,because some of them are also the risk factors for the occurrence of end-target organ damage events,through early intervention against existing risk factors,it will play a positive role in the prevention and treatment of hypertension.Natural factors often can’t be intervented by human forces,therefore,the treatment of the disease lies in the intervention of the controllable factors of the disease to achieve the harmonious state between human and nature.Previous studies on hypertension have mostly observed the pathological aspects of people,such as blood pressure levels and clinical physicochemical indicators,and few studies have focused on human physiology,such as physical fitness related to human body shape,function,and quality.Evaluating the clinical efficacy of the human physiological and pathological state as a whole.Exercise prescription is a disease-oriented,systematic and individualized exercise guidance plan formulated for the individual’s physical fitness and needs.It represents an individualized,scientific and standardized exercise program,and has been used in the treatment of various diseases.Traditional Chinese medicine exercises are effective in the adjuvant treatment of hypertension,but previous studies lack a clear correspondence with "syndrome" and is not well standardized.Traditional Chinese medicine exercise prescription is under the guidance of the TCM basic theories,according to the specific conditions of TCM syndromes of the person who needs exercise prescription,it is a personalized exercise plan which formulates through syndrome differentiation analysis.This study will explore the clinical efficacy of traditional Chinese medicine exercise prescriptions on patients with grade 1 hypertension with low to moderate risk stratification based on the basic treatment principle of "treatment based on syndrome differentiation",in order to explore new treatment views for precision treatment of traditional Chinese medicine.Objective:To explore the clinical effect of traditional Chinese medicine exercise prescription on blood pressure level and related reversible risk factors in patients with grade 1 hypertension with low to moderate risk stratification.Methods:This study is a randomized controlled trial.The patients with grade 1 hypertension with low to moderate risk stratification in the outpatient department and physical examination center of Xiyuan Hospital were selected as the research objects,and they were randomly divided into two groups.The research will last for 4 weeks.The control group was given healthy lifestyle intervention of hypertension,while the experimental group was given TCM exercise prescription on the basis of the control group.The 24 hour mean blood pressure,day and night mean blood pressure,office blood pressure and its total effective rate,TCM syndrome score and its total effective rate,flow-mediated dilation,physical fitness(grip strength,flexibility,balance ability and energy metabolism equivalent),the total average score of the Symptom Checklist90 are used as clinical observations.Comprehensively evaluation the clinical efficacy of personalized traditional exercise prescription on patients with grade 1 hypertension with low to moderate risk stratification.Results:1.General information:A total of 90 patients were included in this study,9 patients were dropped out,81 patients completed research finally.40 cases in the experimental group and 41 cases in the control group.The baseline conditions of two groups were balanced and comparable(p>0.05).2.Main outcome measures:The changes of 24h mean blood pressure in the experimental group and the control group before and after the treatment are statistically significant(p<0.05),After the intervention,the differences in 24h mean blood pressure between two groups are statistically significant(p<0.05),The mean values in the experimental group are greater than control group(p<0.05).3.Secondary outcome measures:3.1 Office blood pressure:There are statistically significant differences in the changes of office blood pressure before and after treatment between the two groups(p<0.05).The differences are statistically significant in office blood pressure between the groups after the intervention(p<0.05).The mean values of blood pressure in the experimental group are higher than those in the control group(p<0.05).3.2 Total effective rate of office blood pressure:After the intervention,the total effective rate of office blood pressure in the experimental group is 72.5%,and in the control group is 48.8%,there is a statistical difference between the groups(p<0.05).3.3 Day and night mean blood pressure:There are statistically significant differences in the day mean SBP,night mean SBP and night mean DBP before and after the intervention in the experimental group(p<0.05),day mean DBP changes are not statistically significant(p>0.05).The day mean DBP changes before and after the intervention in the control group are statistically significant(p<0.05),day mean SBP、night mean SBP and night mean DBP changes are not statistically significant(p>0.05).After intervention,there are differences in day mean SBP,night mean SBP and night mean DBP between the two groups(p<0.05),no statistically significant difference in daytime mean DBP between the two groups(p>0.05).The mean values of day and night mean SBP and DBP in the experimental group are greater than those in the control group,and the difference is statistically significant(p<0.05).3.4 TCM syndrome score:There are differences in the changes of TCM symptom scores in the experimental group(p<0.05),while no differences in the control group(p>0.05).After intervention,the difference in TCM syndrome scores between the two groups is statistically significant(p<0.05),the mean values of TCM syndrome score in the experimental group is significantly greater than that in the control group(p<0.05).3.5 Total effective rate of TCM syndrome score:After intervention,the total effective rate is 85%in the experimental group and 26.8%in the control group,with significant differences between the groups(p<0.01).3.6 FMD:The changes of FMD in the experimental group are not statistically significant(p>0.05),while in control group is statistically significant(p<0.05).There is no significant difference in FMD between the two groups after intervention(p>0.05).FMD mean values in the experimental group are not significantly different from those in the control group(p>0.05).3.7 physical fitness(grip strength,flexibility,balance ability and METs):The changes of grip strength,balance strength and flexibility of the experimental group are statistically significant(p<0.05),the changes of METs in the experimental group are not statistically significant(p>0.05),while the changes of grip strength and METs are statistically significant in control group(p<0.05),the changes of balance strength and flexibility of the control group are not statistically significant(p>0.05),After intervention,the differences in grip strength,balance strength and flexibility between the two groups are statistically significant(p<0.05),the differences in METs between the two groups are not statistically significant(p>0.05),The mean values of grip strength,balance strength,flexibility and METs in the experimental group are greater than those in the control group,and the difference is statistically significant(p<0.05).3.8 The total average score of the SCL-90:There are statistically significant changes in the total average score of SCL-90 in the two groups(p<0.05).After intervention,there is a statistically significant difference in the total average score of SCL-90 between the two groups(p<0.05).The mean values of the total average score of the SCL-90 in the experimental group is greater than that in the control group,and the comparison between the groups is statistically significant(p<0.05).Conclusions:Traditional Chinese medicine exercise prescriptions combined with healthy lifestyle education to intervene in patients with grade 1 hypertension with low to moderate risk stratification for 4 weeks can ameliorate patients’ 24-hour mean SBP and DBP,office SBP and DBP,daytime mean SBP,night mean SBP and night mean DBP,TCM syndrome score,physical fitness level(grip strength,balance,flexibility),psychological status,no adverse reactions were observed during the 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