| Object: To study the relationship between olfactory and nasal structure and nasal mucosa contractility in patients with CRSsNP,and to explore possible related factors affecting olfactory function in patients with CRSsNP,so as to provide reference for clinical treatment of chronic sinusitis.Methods: A total of 50 patients who were diagnosed with CRSsNP in the otolaryngology head and neck surgery inpatient department of our hospital from October 2018 to February 2022 were collected,after excluding 2 patients with a history of nasal surgery,48 patients were finally included in the study,divided into normal olfactory group(n=22)and olfactory disorder group(n=26).Acoustic Rhinometry(AR)was used to detect the nasal cavity structure and nasal mucosal contraction function of patients,include the nasal cavity volume 2-5cm away from the anterior nostril(NV2-5)and the nasal cavity cross-sectional area 4cm away from the anterior nostril(NCA4),The nasal volume change rate(ΔNV2-5)at 2-5 cm from the anterior nostril after 10 minutes of nasal mucosa contraction with 1% ephedrine,withΔNV2-5 representing the nasal mucosa contraction function;The total nasal resistance(NR)of bilateral nasal cavity at 150 Pa was detected by Rhinomanometry(RMM).The subjective olfactory function of the patients was detected by the Sniffin’Stick olfactory stick.There were 22 cases in the olfactory disorder group with a total olfactory score less than or equal to 27,and 28 cases in the normal olfactory group with a total olfactory score greater than 27.All statistical analyses were performed using SPSS software 26.0 statistical software,and P<0.05 was considered statistically significant.Results:(1)There were no significant differences in gender,age,and smoking history between the normal smell group and the smell disorder group(P>0.05),and there was no significant difference in all nasal function test indicators between the two groups(P>0.05).(2)The partial correlation analysis between olfaction and nasal function test indicators after controlling for age showed that olfactory cognition was negatively correlated with ΔNV25,and the partial correlation coefficients were-0.311(P<0.05).(3In the normal olfactory group,after controlling for age,the olfactory threshold was positively correlated with nasal mucosal contractile function(ΔNV2-5),and the partial correlation coefficients were 0.599(P<0.01).But in the olfactory disorder group,there was no significant correlation between the olfactory indicators and the detection indicators.(4)The results of multiple linear regression analysis showed that age(B=﹣0.132,95%CI:﹣0.254,﹣0.009)and NV2-5(B=﹣57.527,95%CI: ﹣ 88.977,﹣ 26.077)were negatively related to the total score of smell Correlation,NCA4(B=48.338,95%CI: 21.181,75.495)was positively correlated with the total score of smell;age(B=﹣0.049,95%CI:﹣0.081,﹣0.018),ΔNV2-5(B=﹣018,95%CI:﹣0.029,﹣0.007)and NV2-5(B=﹣15.727,95%CI:﹣23.809,﹣7.645)were negatively correlated with olfactory cognition,NCA4(B=11.720,95%CI: 4.491,18.648)was positively correlated with olfactory cognition;age(B=﹣0.050,95%CI:﹣0.109,﹣0.009),NV2-5(B=﹣19.928,95%CI:﹣35.023,﹣4.832)was significantly correlated with olfactory recognition.Negatively correlated,NCA4(B=16.924,95%CI: 3.889,29.959)was positively correlated with olfactory recognition.Conclusion: 1.The function of nasal mucosa contraction in patients with CRSsNP do not affect the reduction of olfaction.2.In patients with CRSsNP,with the increase of nasal volume,the sensitivity to the olfaction is reduced.3.Olfactory cognition in patients with CRSsNP may be related to the relative stability of nasal mucosa.4.In patients with CRSsNP,part of the nasal area 4cm from the anterior nostril may also be associated with olfaction. |
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