A Randomized Controlled Clinical Study Of Integrated Traditional Chinese And Western Medicine Cardiac Rehabilitation Program On Chronic Stable Angina Pectoris Of Coronary Heart Disease

OBJECTIVE:The purpose of this research was to study the effects on Integrated Chinese and Western Medicine Cardiac Rehabilitation Program on cardiopulmonary function,coronary heart disease risk factors and quality of life of patients with stable angina pectoris.METHODS:A total of 72 patients with stable angina pectoris who met the inclusion and exclusion criteria were selected in the outpatient department of Cardiology,Guang’anmen Hospital,Chinese Academy of Chinese Medical Sciences.Among the 72patients,36 cases were admitted to the control group and routine western medicine treatment for coronary heart disease,while 36 cases were admitted to the experimental group,and received the integrated Traditional Chinese and Western medicine cardiac rehabilitation program,the observation period was 3 months.The VO2max value,6minute walking test(6MWT)value,body mass index(BMI),blood glucose(GLU)level,uric acid(UA)level,homocysteine(Hcy)level,C-reactive protein(CRP)level,serum total cholesterol(TC)level and high density lipoprotein cholesterol(HDL-C)level、low density lipoprotein cholesterol(LDL-C)level,triglyceride(TG)level,life quality Assessment Scale(SF-36)score,Self-rated Anxiety scale(SAS)score,Selfrated Anxiety Scale(SDS)score and Seattle Angina questionnaire(SAQ)total score,were compared between experimental group and control group before and after intervention,All data were analyzed by SPS22.0 statistical software.RESULTS:1.72 patients with stable angina pectoris of coronary heart disease were enrolled,of which 7 cases fell off,a total of 65 patients completed the experiment.33 cases in the control group while 32 cases in the experimental group.There was no significant difference between the two groups in gender,age,course of disease,smoking and drinking history,co-morbidities,and baseline data for the indicators that we’re observing.(P>0.05)2.Body mass index(BMI):After 3-month intervention,the BMI of the patients in the experimental group significantly reduced compared with those before the intervention and after the intervention in the control group(P<0.05);3.Cardiopulmonary function:After the 3-month intervention,the VO2max value and 6MWT value of the experimental group were significantly improved compared with those before the intervention and the control group after the intervention(P<0.05);4.Angina pectoris attack:Seattle Angina questionnaire(SAQ)total score:After 3 months of intervention,the total score of the experimental group was significantly higher than that before the intervention and the control group after the intervention(P<0.05);5.Coronary risk factor:After 3 months intervention,blood glucose(GLU),total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),C-reactive protein(CRP),serum homocysteine(Hcy)and uric acid(UA)were significantly decreased compared with those before intervention(P<0.05).There was no significant difference in high-density lipoprotein before intervention(P>0.05).After 3 months intervention,the levels of fasting blood glucose(GLU),total cholesterol(TC),triglyceride(TG),C-reactive protein(CRP),serum homocysteine(Hcy)in patients decreased compared with control group.There were no significant differences in low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)and uric acid(UA)levels compared with control group(P>0.05).6.Quality of life and psychological state:After the 3-month intervention,the SF36 score of the experimental group was significantly higher than that before the intervention and the control group after the intervention(P<0.05);the SAS and SDS scores were lower than those before the intervention and the control group(P<0.05).7.Safety evaluation:During the intervention,there were no major adverse cardiovascular events in the two groups,no sports injuries occur in the experimental group.8.At the 6-month follow-up,there were no significant differences in SF-36 score,SAS score,SDS score and total score of SAQ between experimental groups and after intervention(P>0.05);There were significant differences between the test group and the control group in the scores of each scale during 6-month follow-up(P<0.05).CONCLUSION:Patients with stable angina pectoris of coronary heart disease received Integrated Chinese and Western Medicine Cardiac Rehabilitation 3 months later,the patients’cardiopulmonary function,angina pectoris attack,coronary heart disease risk factors,psychological state and quality of life have been significantly improved.Integrated Chinese and Western Medicine Cardiac Rehabilitation Program is with good efficacy and safety.