| In recent years,the incidence of ulcerative colitis(UC)has increased year by year,with the characteristics of long course and easy recurrence,while having a high risk of carcinogenicity,seriously affecting the quality of life,and even threatening life health.At present,the cause of the disease is not clear,the treatment is mainly to inhibit symptoms and delay the progression of the disease,there is no radical cure,which has increased the burden on public health.The commonly used clinical treatment methods have the disadvantages of more adverse reactions or need to have strict indications,and are limited by region,economic level and medical conditions,and cannot be widely used.Therefore,the search for simple,affordable,safe and effective treatment methods plays an important and key role in UC treatment.Traditional Chinese medicine enema treatment of diseases has a long history,combined with the overall concept and dialectical treatment characteristics,in the treatment of UC has achieved a certain efficacy,its no oral,economic safety,direct efficacy characteristics,so that Chinese medicine enema compliance is good,high clinical acceptance,has a unique advantage.Kuyu Qing enema formula in the clinical treatment of UC has achieved a certain curative effect,the treatment of intestinal detoxification and dampness,detoxification and cool blood and diarrhea-based,the formula to indigo naturalis,forsythia,fried gardenia,Paeonia lactiflora Pall,Ebony,elm charcoal,licorice,glauber’s salt,Bletilla striata.Jun with indigo naturalis,fried gardenia,forsythia to clear the heat and fire,cool blood detoxification,subject to the earth elm charcoal,white and,wumei,mango salt convergence to stop bleeding,astringent intestines to stop diarrhea,accompanied by Paeonia lactiflora Pall to nourish the blood yin,so that licorice to strengthen the spleen,and mix various medicines,both detoxification.Modern studies have shown that Traditional Chinese medicines and active ingredients such as indigo naturalis,Forsythia,and Fried Gardenia have the effects of anti-inflammatory,repairing intestinal mucosa,balancing immunity,regulating intestinal flora,etc.,and act on UC pathogenic targets through signaling pathways,effectively inhibiting inflammation,alleviating symptoms,slowing disease progression,improving patients’ quality of life,and reducing socioeconomic burden.The tutor has been engaged in scientific research and clinical work for nearly thirty years,has accumulated a lot of experience,and inherited the successful experience of predecessors,established a unique academic thinking,proposed that UC diseases are always closely related to the damp heat of the intestine,heat poisoning into the blood,combined with the characteristics of Beijing climate,eating habits and social pressure characteristics,according to the conditions of the time and place,the clinical dialectical consideration of summarizing the treatment is mainly based on the damp heat of the large intestine,and through the ulceration of the enema,the intestine is cleared,the detoxification is cool and the blood is stopped.objectives:The treatment group and control group of this study were treated based on oral mesalazine entericcoated tablets,with rehabilitation of new liquid enema therapy as a positive control group,with Kuiyu Qing retaining enema as the treatment group,combined with the tutor’s clinical application of UC experience,using modern statistical analysis methods,to test the clinical application effect of Kuiyu Qing,providing valuable reference and reference for traditional Chinese medicine in the treatment of UC.Methods:In this study,randomized controlled experiments were conducted to select patients with ulcerative proctitis or left hexacolitis who were diagnosed with mild to moderate disease,hot and humid color of the large intestine,nascent or chronic recurrent ulcerative proctitis or left hexocolitis from October 2020 to December 2021.A total of 62 patients were selected and divided into a treatment group and a control group,of which 32 cases were treated in the treatment group,30 cases in the control group,and both groups were given Western medicine mesalazine enteric-coated tablets 1g 3/day orally,while the treatment group was given Kuiyu Qing to retain enema treatment,and the control group was given rehabilitation new liquid enema treatment,with twentyeight days as a course of treatment,recording the baseline data of the gender,age,course of illness of the enrolled patients,and the efficacy evaluation was mainly the TCM symptom rating scale,the efficacy of TCM symptoms,and the improved Mayo index.After the end of treatment,the data was collated and the statistical analysis was performed through spss statistical software to evaluate the treatment effect.The incidence of adverse reactions,blood routine,liver and kidney function,and twelvelead electrocardiogram of the two groups during the treatment process were observed,and the safety evaluation was carried out.results:A total of 68 participants were included in this study,34 cases in the control group,34 cases in the treatment group,2 cases in the treatment group shedding,4 cases in the treatment group shedding,and finally 62 cases,32 cases in the treatment group,30 cases in the control group,and there was no statistical significance between the treatment group and the control group in terms of age,sex,course,pre-treatment TCM symptom score,modified Mayo index score,and TCM syndrome score(P>0.05),all are comparable.After treatment,the number of clinically effective people in the Chinese medicine enema group was 30 people,the clinical effective rate was 93.75%,and the rehabilitation new liquid enema group reached 21 people with clinical effectiveness,the clinical effective rate was 70%,by using the chi-square test,the P value<0.05,the difference was statistically significant,indicating that the Kuiyu Qing formula enema prescription had more advantages than the rehabilitation new liquid enema prescription in improving the clinical efficacy of traditional Chinese medicine symptoms.After treatment,the modified Mayo index of the Chinese medicine enema group was lower than that before treatment,and the P-value was<0.5 by using the Wilcoxon sign rank test,indicating that the comparison between the group before and after treatment was significant,and the ulcerative enema could significantly reduce the improved Mayo activity index.The modified Mayo index of the rehabilitation new liquid enema group after treatment was lower than that before treatment,and the P-value was<0.5 by using the Wilcoxon sign rank test,indicating that the improved Mayo activity index was significantly different in the group before and after treatment,and the modified Mayo activity index could also be significantly reduced in the rehabilitation new liquid enema treatment.A comparison between the two groups after treatment,by using the Mann-Whtiney U test,had a P-value of<0.05 in terms of blood in the stool and total score,indicating that there was a significant difference between the Kuiyu Qing formula side and the rehabilitation new liquid enema in improving the improved Mayo activity index,especially in improving the symptoms of blood in the stool.The Kuiyu Qing formula(0.5(0,2))is superior to the rehabilitation new liquid enema treatment(1(0,3)),indicating that although both groups can improve the Mayo index,the Kuiyu Qing formula has a more obvious improvement effect,especially for improving blood in the stool,which is more advantageous.Through the Wilcoxon symbol rank test,the P value of the main symptoms and secondary symptoms before and after the treatment of the Chinese medicine enema group was<0.05,and the contrast between the main symptoms and the secondary symptoms before and after the treatment was significant,indicating that the Kuiyu Qing formula could effectively alleviate the symptoms,and the comparison between the rehabilitation new liquid enema group before and after treatment,by using the Wilcoxon symbol rank test,it was obtained that in terms of diarrhea,mucus pus and blood stool,tenesmus and symptom summary,the P value<0.05,and the P value of the rest of the symptoms was>0.05,indicating that the rehabilitation of new liquid enema in diarrhea,mucus pus bloody stool,tenesmus and symptom summary is of statistical significance,the rest of the symptoms are not different,there is no statistical significance,indicating that the rehabilitation of new liquid enema therapy can effectively alleviate diarrhea,mucus pus blood stool,tenesthus and the total symptoms,but in improving abdominal pain,burning,shortness of urine,bloating,dry mouth and bitter symptoms,the effect is not obvious.After treatment,the P-value was<0.05 in terms of diarrhea,mucus pus and bloody stool,abdominal pain,burning,bloating,dry mouth and bitter mouth,and total integral,and the difference was statistically significant,and the P-value was>in terms of tenesmus and shortness of urine 0.05,the difference was not statistically significant,indicating that the two groups had the same effect on improving the symptoms of tenesmus and shortness of urine,and the ulcerative enema prescription treated diarrhea(2(0,2)),mucus pus and bloody stool(1(0,2)),abdominal pain(2(0,2)),burning(0.5(0,1)),abdominal distension(1(0,1)),dry mouth pain(1(0,1)),total integral(5(3,2)),rehabilitation of new liquid enema for diarrhea(2(0,4)),mucus pus and blood stool(2(0,4))Abdominal pain(2(0,10)),burning(1(0,4)),bloating(1(0,3)),dry mouth(1(0,3)),total integral(12(6,21)),indicating that the ulcerative and clearing enema side is better than the rehabilitation of new liquid enema therapy in terms of improving diarrhea,mucus pus and bloody stool,abdominal pain,burning,bloating,dry mouth,and total integrals,and has a better effect on improving symptoms.Conclusion:By observing the Kuiyu Qing formula combined with the Western medicine mesalazine,the treatment of mild to moderate active ulcerative colitis patients with lesions in the rectum and left half colon by combining the Kuiyu Qing formula with the Western medicine mesalazine,the control group was cured by combining the new liquid enema with Western medicine orally,and the conclusions were as follows:the overall efficacy before and after the treatment of the two groups was compared,the control group recovered 4 cases,the effective group was 70%,the effective 10 cases were effective,the effective 9 cases were 90%,the treatment group was cured 10 cases,the effect was 10 cases,the effective 10 cases,the ineffective 2 cases,and the total effective rate was 93.75%.The effectiveness difference between the two groups was statistically significant(P<0.05),and the effectiveness rate of the treatment group was significantly higher than that of the control group,and the Kuiyu Qing formula could effectively improve the clinical efficiency.The efficacy of traditional Chinese medicine symptoms in the treatment group was significantly better than that in the control group,and the symptoms of abdominal pain,diarrhea,mucus and pus,bloody stool,dry mouth,burning,and short urine were significantly improved by statistical analysis(P<0.05).The treatment group was significantly better than the control group in the modified Mayo index,and significantly improved the symptoms and total score of blood in the stool,and the difference was statistically significant(P<0.05).All patients did not see obvious abnormalities in blood routine,liver and kidney function,and electrocardiogram before and after diagnosis and treatment,and no obvious adverse reactions were seen in both groups during diagnosis and treatment.The results showed that the treatment of Kuiyu Qing formula combined with Western medicine had more advantages than the rehabilitation of new liquid enema combined with Western medicine therapy,and the safety was higher,and the clinical promotion and application of value. |
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