Objective: the purpose of this study is to observe the clinical efficacy and safety of zadi-5wei pill in the treatment of patients with Heyi jirudaoligsule,and to provide a new idea for the treatment of Heyi jirudaoligsule with the combination of Mongolian and Western medicine.Methods: This study screened 60 patients who met the diagnostic criteria and inclusion criteria.They were randomly divided into two groups,30 cases in the control group and 30 cases in the treatment group.Control group: 100 mg propafenone tablets were taken with warm boiled water in the morning,afternoon and after dinner.Treatment group: on the basis of the treatment of the control group,15 zadi-5 pills were taken in the morning and after dinner,with warm boiled water.The observation time was 4 weeks.The symptom scores,total scores,total clinical efficacy and the number of premature beats in24-hour ambulatory electrocardiogram were compared between the two groups before and after treatment,and the effects on blood routine,liver function,renal function,urine routine and other safety indexes were observed before and after the experiment.result:1.Before treatment,there was no significant difference between the two groups in age,gender,distribution of atrial premature beats and ventricular premature beats,symptom scores and total scores of Mongolian Medicine(P > 0.05).2.Comparison of clinical symptom improvement between the two groups:Compared between the two groups before treatment,the P values of all symptoms of Mongolian medicine were > 0.05,there was no statistical difference and comparable.After treatment,the symptom scores of the two groups were improved,and the P < 0.05 between the two groups was statistically significant.The treatment group was better than the control group.Intra group comparison: after treatment,the symptoms of the two groups were improved,P < 0.05,which was statistically significant.The improvement of palpitation,insomnia,fatigue and dreaminess in the treatment group was better than that in the control group.3.Comparison of total clinical effective rate between the two groups after treatment:In the treatment group,13 cases were markedly effective(43.3%),13 cases were effective(43.3%),4 cases were ineffective(13.4%),and the total clinical effective rate was86.6%.In the control group,10 cases were markedly effective(33.3%),13 cases were effective(43.3%)and 7 cases were ineffective(23%),and the total clinical effective rate was 76.6%.There was significant difference between the groups(P < 0.05).The treatment area was better than the control group.The number of patients in the treatment group was significantly lower than that in the control group(P < 0.05).5.By observing the blood routine,liver function,renal function and urine routine of the patients in the treatment group and the control group,there was no significant difference before and after treatment(P > 0.05),and there were no obvious abnormalities and side effects.Conclusion:1.Mongolian medicine zaidi-5wei pill can significantly improve the clinical efficacy in the treatment of Heyi jirudaolig Sule disease.2.Mongolian medicine Heyi type treatment can significantly reduce the number of premature beats without adverse reactions,which is worthy of clinical promotion. |