Quantitative Study Of Pancreatic Fat Infiltration In Type 2diabetes Patients By Siemens 3.0 T Six-Echo Dixon Technique

Objective :1.The purpose of this study was to discuss the value of Siemens 3.0 T magnetic resonance q Dixon-WIP sequence in the determination of fat content in patients with type 2 diabetes.2.to explore the relationship between the parameters and the normal group during the development of type 2diabetes.3.investigate the relationship between the course of type 2 diabetes and pancreatic fat infiltration.Materials and methods: From April 1,2019 to January 10,2021,A total of36 women(17 T2 DM patients),19 normal controls),59 males(30 T2 DM,29normal controls),All subjects were examined by the same technician with rich experience in magnetic resonance machine operation.Scanning instrument:abdominal axial scanning(Magnetom Verio;)with 3.0 T MR instrument Siemens,Erlangen,Germany).A scan sequence is a q Dxion-WIP sequence.Post-processing by two doctors familiar with the radiology department,To draw FF area of interest independently(ROI)on the resulting map,directly measure the fat percentage value of the region(ROI)of interest.Select 4(liver S2/3、S4、S5/8、S6/7)areas of interest in the liver(ROI),And measure its corresponding Goodness of fit,(good<5 per cent),Try to avoid the intrahepatic sink area.At the pancreas,3 areas of interest(head,body,tail)were selected(ROI),And Goodness of fit.the same Calculate the average value of each index respectively.At the same time upload images to ziastationg,After processing,The intraperitoneal fat area,abdominal wall fat area and pancreatic volume of experimental group and normal group were obtained.Clinical data of patients were searched through the HIS system of the First Affiliated Hospital of Guangxi Medical University;The height and weight of the normal control group were measured on the same day.Statistical analysis using SPSS22.0 software for statistical analysis,(P<0.05 was statistically significant).Results:1.T2 DM group BMI、 pancreatic body ratio,abdominal wall fat area,intraperitoneal fat area,cholesterol,triglyceride,high density lipoprotein and normal control group BMI、 pancreatic body ratio,abdominal wall fat area,intraperitoneal fat area,pancreatic fat content(PFF),liver fat content(HFF)were all normal distribution.2.There was no significant difference in BMI between T2 DM patients and normal groups(P>0.05).There were significant differences in pancreatic body ratio,abdominal wall fat area,wall fat area,intraperitoneal fat area,pancreatic fat content and liver fat content(P<0.05).The pancreatic body ratio was lower than that of normal group.3.The PFF of T2 DM group was positively correlated with HFF,The correlation coefficient is r0.964(P=0.000);It was positively correlated with triglyceride,abdominal fat area,The correlation coefficients r 0.676(P=0.000),0.591(P=0.000),There was a weak positive correlation with abdominal fat area,The correlation coefficient is r 0.321(P=0.033);There was no correlation with fasting blood glucose,cholesterol,pancreatic body ratio,HDL,LDL,The correlation coefficients r0.385(P=0.194),0.236(P=0.437),-0.163(P=0.292),-0.168(0.276),-0.002(P=0.987).There was no significant difference between ≤1 year and 1 year < the course of disease in the T2 DM group,PFF values between the two groups can not be considered to be different.There was a significant difference between <5-year group and the 5-year ≥ group,PFF values between the two groups can be considered to be different.Conclusion:This study confirmed that the qdixon-WIP sequence is more stable,accurate and reproducible,which can provide a reference for clinical evaluation of pancreatic fat.It was confirmed that the ratio of pancreatic body PFF、T2DM patients in T2 DM group was lower than that in normal group,while that in abdominal wall,abdominal cavity and PFF、HFF were higher than that in normal group;The PFF of T2 DM patients was positively correlated with HFF、triglyceride,abdominal fat area and abdominal wall fat area,and wirelessly correlated with pancreatic body ratio,cholesterol,high density lipoprotein,low density lipoprotein and fasting blood glucose.This study confirmed that the accumulation of pancreatic fat in patients with long course was higher than that in patients with short course,but the effect of intervention was not excluded,and its effect on insulin resistance and pancreatic fat deposition could not be excluded.