An Evaluative Study Of Postoperative Complications After Pancreatic Endoscopic Ultrasound-guided Fine-needle Aspiration Biopsy

Objective:To evaluate the safety of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)in the diagnosis of pancreatic space occupying lesions,and to analyze the relationship between the occurrence of related adverse events and indicators.Methods:A total of 469 patients diagnosed with pancreatic spaceoccupying lesions and perfected EUS-FNA examinations in the First Affiliat-ed Hospital of Guangxi Medical University from January 2015 to Decem-ber 2020 were retrospectively analyzed.In these cases,there are 264 cases with complete data and in line with the enrollment.The patient’s age,gender,preoperative serum amylase,preoperative white blood cell count,serum amylase 2 hours postoperatively,white blood cell count 2 hours postoperatively,serum amylase24 hours postoperatively,white blood cell count 24 hours postoperatively and other data were collected.The auth-or used multivariate logistics regression analysis to understand the relevant factors affecting adverse events after EUS-FNA.Results: Among the 264 patients,25 patients had adverse events with mainly hyperamylasemia and abdominal pain,no serious complications such as postoperative acute pancreatitis,pancreatic fistula,gastrointestinal perforation,and gastrointestinal bleeding,with an incidence rate of 9.4%.Among them,there were 17 patients(6.4%)with abdominal pain and 8 patients(3.0%)with hyperamylasemia.Among the patients with hyperamy-lasemia,6 patients(2.2%)appeared 2 hours postoperatively,and the other 2 patients(0.7%)appeared 24 hours postoperatively.The patients with adverse events were divided into hyperamylasemia group and abdominal pain group.Multivariate logistic regression analysis of the two groups fo-und that patients with high preoperative serum amylase were more likely to have hyperamylasemia than patients with low preoperative serum amy-lase,and the difference was statistically significant(P<0.05).When preop-erative serum amylase increases by a unit,the probability of hyperamylas-emia increases by 1.2%(OR=1.012).Conclusion: The main adverse events in patients after EUS-FNA were abdominal pain and hyperamylasemia.There were no serious complicati ons such as postoperative acute pancreatitis,gastrointestinal perforation,hemorrhage,and needle implant transfer.Hyperamylasemia after EUS-FN A usually occurs within 2 hours postoperatively.The application of EUS-FNA in pancreatic space-occupying lesions is safe.