Analysis Of Prognostic Factors In Patients With Triple-Negative Breast Cancer

Purpose:To explore the relevant clinical characteristics and prognostic factors of patients with triple-negative breast cancer after surgery.Methods:This study retrospectively included 160 patients with triple-negative breast cancer admitted to the First Affiliated Hospital of Guangxi Medical University from May 2012 to April 2016,and collected general data（age of onset,menstrual status,family history）,tumor pathology Features（histological grade,tumor T staging,lymph node staging,Ki-67 expression status）and treatment status（surgical method,neoadjuvant chemotherapy,postoperative radiotherapy,postoperative adjuvant chemotherapy）.Kaplan-Meier was used to calculate the survival rate and draw the survival curve,the Log-rank test was used to screen the factors affecting the patient’s prognosis,and the Cox model was used for multivariate analysis of statistically significant single factors.Result:The last follow-up time was April 3,2021,the follow-up time was60-108 months,and the median follow-up time of the whole group was 72months.1.Univariate analysis results:age,family history,surgical methods,menstrual status,pathological type,histological grade,Ki-67 status and the prognosis of triple-negative breast cancer patients have no correlation,P>0.05,No statistical significance.Tumor T staging,lymph node staging,neoadjuvant chemotherapy,postoperative radiotherapy,and postoperative adjuvant chemotherapy are related prognostic factors that affect OS in patients with triple-negative breast cancer.Tumor T staging,lymph node staging,neoadjuvant chemotherapy,and postoperative radiotherapy are three factors that affect OS.Prognostic factors related to LRR in patients with negative breast cancer after surgery,tumor T staging,lymph node staging,neoadjuvant chemotherapy,and postoperative adjuvant chemotherapy are related prognostic factors that affect DM in patients with triple negative breast cancer after surgery.2.The prognostic survival analysis results of different adjuvant chemotherapy regimens:OS and DMFS of patients with anthracycline+taxane regimen are better than those of other chemotherapy regimens,P<0.05,the difference is statistically significant.3.The prognostic survival analysis results of 83 subgroups of T_1-2N₀M₀radiotherapy group and non-radiotherapy group:The OS of the radiotherapy group is better than the patients of the non-radiotherapy group,P<0.05,the difference is statistically significant.The LRFS of the radiotherapy group,DMFS was better than the patients in the non-radiotherapy group,P>0.05,the difference was not statistically significant.4.The results of multivariate analysis showed that lymph node staging was an independent risk factor for OS,LRR,and DM in patients with triple-negative breast cancer（P<0.05）,and postoperative radiotherapy was an independent prognostic factor for OS,LRR,and DM in patients with triple-negative breast cancer（P<0.05）,tumor T staging is an independent risk factor for DM in patients with triple-negative breast cancer（P<0.05）.Concusion:1.Tumor T staging,lymph node staging,neoadjuvant chemotherapy,postoperative radiotherapy,postoperative adjuvant chemotherapy are of great significance to the prognosis of triple-negative breast cancer patients.2.Tumor T staging,lymph node staging,and postoperative radiotherapy are independent prognostic factors for triple-negative breast cancer patients.3.For patients with triple-negative breast cancer,postoperative adjuvant chemotherapy is preferred to anthracycline+taxane chemotherapy.4.Postoperative radiotherapy can increase the local recurrence rate of triple-negative breast cancer patients to a certain extent and improve the overall survival rate of patients.Even patients with early triple-negative breast cancer can benefit from postoperative radiotherapy.