Clinical Study Of New Molecular Gd-G2-PEG、Gd/Bi-G2

Contrast enhancement is an important means of clinical imaging diagnosis.the introduction of contrast agent greatly improves the resolution of tissue imaging.A small molecule iodine-containing contrast agent and gadolinium-containing contrast agent are the most commonly used CT、MR contrast drugs in clinic.Practice shows that the relaxation efficiency of commonly used dosage forms is limited,the effective cycle period in vivo is short,the target function is lacking,and will cause many side effects.Therefore,it is urgent to develop novel and efficient imaging molecules.the dendrite-like structure-based nanography molecules are a class of known ideal materials.in this topic,we systematically evaluated the functional traits and clinical application efficacy of the Gd-G2-PEG and Gd/Bi-G2d of the two novel synthetic materials in order to promote the continuous optimization of contrast agents and serve the clinic at an early date.The first chapter:this part systematically clarifies the background of our research and the research status of contrast agent field.Based on the basic principles of magnetic resonance imaging、CT imaging and CAs,the practical problems to be solved in the development of contrast agent,and the basic situation of all kinds of new synthetic materials are introduced.The research status of dendritic macromolecules related to the content of this paper is emphasized.chapter Ⅱ:this section systematically verifies the comprehensive properties of Gd-G2-PEG materials molecules.Gd-G2-PEG relaxation performance is superior to the commonly used magnetic resonance contrast agents in clinic;in animal trials,it can efficiently enhance the contrast of tissues and organs in vivo and has certain tumor targeting function;the optimization of molecular structure and the modification of surface groups enhance the biological safety of new molecules.Chapter Ⅲ:the related properties of molecular Gd/Bi-G2 of CT、MR bimodal contrast agent are studied.bimetallic co-load achieved efficient biological function,the enhancement effect of in vivo and exography was better than that of common CT、MR contrast agents;the development of bimodal molecules for upper gastrointestinal imaging,bimodal synergistic realization of diagnostic synergy,high diagnostic efficiency;biological toxicity study,from the cellular,tissue level confirmed that this macromolecule in vivo better metabolic stability,no significant systemic toxicity.To sum up,the two new molecules have obvious advantages over the commonly.used comparative dosage forms,which further confirm the scientific nature of the PDOTA synthesis strategy and its excellent performance in practical function and toxicological safety.It can be considered as an ideal molecular imaging material.The research in this paper can provide theoretical basis for its further clinical transformation and contribute to the construction of more perfect imaging materials in the future.