Reticular Meta-analysis Of The Efficacy Of Agartreban Vs Batroxase In The Treatment Of Progressive Cerebral Infarction

Background:Progressive stroke,as a common type of acute ischemic stroke with a poor prognosis,is increasingly attracting the attention of many neuroscience researchers and neurology clinicians.Because its definition,pathogenesis,etc.are still unclear,so we recognize a major problem in our work for its clear and effective treatment.A review of the literature found that the common drugs used for progressive stroke are argatroban,tirofiban,batroxobin,edaravone and other drugs.Argatroban(Argatroban)is a synthetic piperidine carboxylic acid derivative of L-arginine,which acts both in vivo and in vitro.It has a highly selective reversible non-specific direct thrombin inhibitor.The onset of action is fast,the half-life is short,and the risk of bleeding is small.Batroxobin is a snake venom extract that can reduce fibrinogen,and has a certain risk of bleeding.Its application in the early stage of acute ischemic stroke has not yet been accurately certified,so It is difficult for everyone to have a clear and comprehensive understanding of its efficacy.Objective:To compare the efficacy of Argatroban and Batroxobin in the treatment of progressive stroke.Methods:A computer search of RCT,CCT and a retrospective case-control study on argatroban and batroxobin in the treatment of progressive stroke in databases such as China HowNet,PubMed,Cochrane,GeenMedical,Web of Science,etc.The search time limit is from January 2000 to January 2021.The Chinese search terms are"Argatroban,Dabbe,Batroxobin,Tonlinketase,Progressive Stroke,Acute Ischemic Stroke,Early Nervous System Function Deterioration",etc.English search terms are"Progressive stroke,advanced stroke,progressive stroke,stroke in progression,progressive stroke,stroke in progression,SIP,Early neurological function deteriorates,Ischemic Strokes,Cryptogenic Ischemic Stroke,Ischemic Stroke,Cryptogenic,Stroke,Cryptogenic Ischemic,Cryptogenic Stroke,Cryptogenic Strokes,Stroke,Cryptogenic,Cryptogenic Embolism Stroke,Cryptogenic Embolism Strokes,Embolism Stroke,Cryptogenic,Stroke,Cryptogenic Embolism;batroxobin,Defibrol,Defibrase,Hemocoagulase;argatroban,argatroban monohydrate,argatroban hydrate.Use subject words and free words to match,("Progressive stroke"[MeSH Terms]OR "advancing stroke"[All Fields]OR "Early neurological function deteriorations"[All Fields])AND("batroxobin"[MeSH Terms]OR("Defibrol"[All Fields]OR"Defibrase"[All Fields]OR"Hemocoagulase"[All Fields]))AND("argatroban"[MeSHTerms]OR("argatroban monohydrate"[All Fields]OR"argatrobanhydrat"[All Fields])AND("2000/01/01"[PDat]:"2021/01/21"[PDat]),use the corresponding Boolean logic operator to connect to search,a total of 532 documents were retrieved.And the original documents retrieved and related Expanded search for references of Meta analysis,using Bayesian-based network Meta processing software Stata 15.0 for data statistics and analysis of documents that meet the inclusion criteria.Results:A total of 13 studies have been included in this article to evaluate Argatra.Ban compared the efficacy of batroxobin in the treatment of progressive cerebral infarction,with a total of 1485 patients,including 730 in the control group and 755 in the observation group(n=413 in the argatroban group and n=342 in the batroxobin group).Compared with the group,argatroban has a higher effect in the treatment of acute progressive stroke,(SMD and its 95%CI are greater than 0,and does not contain 0).There is a statistical difference.It is considered that argatroban combined with aspirin treatment progress Stroke is more worthy of application.Argatroban is compared with batroxobin combined with aspirin in the treatment of progressive stroke.Tips:Argatroban combined with aspirin is the highest(SUCRA=75.3%,MeanRank=1.5),batroxobin combined with aspirin Second(SUCRA=74.7%,MeanRank=1.5),aspirin alone third(SUCRA=0,MeanRank=3.0).Conclusion:The efficacy of argatroban combined with aspirin in the treatment of progressive stroke is significantly higher than that of the control group.Sort by SUCRA In view of this,argatroban combined with aspirin has the highest efficacy in the treatment of acute progressive stroke.It is expected to become an effective treatment plan for the treatment of acute progressive stroke and improve the prognosis,helping clinicians to effectively treat acute ischemic cerebrovascular disease,So that patients can get more ideal treatment.