| Objective:To study the effect of uric acid on large-artery atherosclerosis ischemic stroke patients,and to explore the relationship between uric acid and large-artery atherosclerosis ischemic stroke cerebral short-term illness,and 90-day prognosis.To Provide scientific basis for the prevention and treatment of large-artery atherosclerosis ischemic stroke.Method:A retrospective case-control study was carried out on 132 patients who were admitted to the Department of Neurology from October 2015 to October 2017 in the Third Affiliated Hospital of Guangzhou Medical University.The condition,past history,and laboratory data of LAA cerebral infarction patients at admission were collected to observe short-term disease changes and the prognosis after 90 days of follow-up.The previous serum uric acid was used as the basis for uric acid in patients with cerebral infarction before admission(Basal uric acid).Basal uric acid and uric acid on admission were divided into three levels according to uric acid level;the difference between basal uric acid and admission uric acid was defined as uric acid changes(uric acid changes =admission uric acid-basal uric acid),uric acid changes > 0 for uric acid increased,uric acid changes <0 for uric acid decreased.The patients were divided into progressive cerebral infarction group(progressive group)and non-progressive cerebral infarction group(non-progressive group)according to short-term disease changes.The increase of NIHSS score of 2 points or more after admission was defined as progression group,and the NIHSS score of hospital admission was insufficiently increased.2 points or less is defined as a non-progressive group.The 90-day prognosis of patients was divided into good prognosis group and poor prognosis group: m RS score <3 was defined as good prognosis group,and m RS score ≥ 3 was defined as poor prognosis group.Unconditional LOGSTIC regression was used to analyze the relationship between uric acid and atherosclerotic cerebral infarction in patients with severity of admission,short-term illness,and prognosis.Rusult:(1)Analysis of related factors affecting short-term disease changes: Univariate analysis showed that among the 14 factors that may affect short-term disease changes,differences in uric acid changes,blood glucose,and high cholesterol in different short-term disease-change groups Statistical significance(all P<0.05).Multivariate nonconditional LOGISTIC regression analysis adjusted for confounding factors.Onset time,uric acid changes,and high cholesterol were still associated with worsening short-term conditions.The risk of progressive cerebral infarction due to a decrease in uric acid was 4.160 times higher than the increase in uric acid(P<0.05).The decrease in uric acid was a risk factor for progressive cerebral infarction.(2)Analysis of the factors that influence prognosis: Univariate analysis showed that among the 15 factors that may affect short-term disease changes,the differences in baseline uric acid,admission NIHSS score,hyperglycemia,and high cholesterol in different prognostic groups were statistically significant.Significance(all P<0.05).The incidence of poor prognosis in patients with low basal uric acid levels,moderate basal uric acid levels,and high baseline uric acid levels was 41.9%,18.2%,and 55.5%,respectively.The incidence of poor prognosis in moderate basal uric acid was significantly lower than that in low basal uric acid and high uric acid.Level.Using moderate basal uric acid levels as a reference,multi-factor non-conditional LOGISTIC regression analysis adjusted confounding factors,and admission NIHSS scores and basic uric acid were still associated with poor prognosis.The risk of poor prognosis of the low-basal uric acid and high-basic uric acid levels was 4.823 and 9.526 times that of the moderate-basic uric acid respectively,and the differences were statistically significant(P<0.05).It was shown that different levels of uric acid present a U-shaped relationship for the risk of poor prognosis in atherosclerotic cerebral infarction.Conclusions:(1)The levels of uric acid and uric acid levels in hospitals were not related to the short-term conditions in patients with atherosclerotic cerebral infarction.Changes in uric acid were related to the short-term conditions in patients with atherosclerotic cerebral infarction.After adjustment for confounding factors,the decrease of uric acid was still a risk factor for patients with progressive large atherosclerotic cerebral infarction.(2)Urinary acid levels and uric acid changes on admission were not associated with a 90-day prognosis in patients with atherosclerotic cerebral infarction.Base uric acid levels were associated with a 90-day prognosis in patients with atherosclerotic cerebral infarction.After adjustment for confounding factors,different baseline uric acid levels showed a U-shaped relationship for the risk of poor prognosis in patients with large atherosclerotic cerebral infarction,and lower or higher levels of basic uric acid were not conducive to the 90-day prognosis of patients with large atherosclerotic cerebral infarction. |
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