Comparison Of TOF And PSF PET Image Reconstruction Technology’s Influence On Quantitative Parameters Of Tumor Lesions

Objective:Contrastively analyze the effect of TOF-PET and PSF-PET reconstruction technique for18F-FDG metabolic parameter of different part of the body and different of malignat lesions.Methods:Analyze respectively 270 cases of 18F-FDG PET/CT-treated primary malignat tumor infected individuals in several hospitals(Shengjing Hospital,Tianjing Tumor Hospital and the Inner Mongolia Hospital),121 male patients and 149 female patients with an average age of 59.07±11.82(range:29-87 years old),23.92±3.35(range:16.61-34.34)of BMI,97 cases of chest tumor,62 of abdominal tumor,104 of pelvic tumor and 9 of superficial tumor,and 4.16±2.27cm(0.5～15.2cm)of Dmax.Reconstruct the PET/CT data according to VUE Point HD,TOF+ VUE Point HD,Sharp IR+VUE Point HD and TOF+Sharp IR+ VUE Point HD,in which VUE Point HD(GE Healthcare)is 3D iteration reconstruction technique and Sharp IR(GE Healthcare)is the PET image reconstruction technique based on PSF technology.Apply PET VCAR on AW station for image processing and measurement of 18F-FDG metabolic parameter(SULmean、SULmax、 SUVmean、 SUVmax)to calculate the change rate(%).Apply independent sample to analyze the comparation of change rate of TOF,PSF and TOF+PSF parameters.Results: :TOF and PSF are both useful to improve the metabolic parameters of all malignant lesions,and TOF+PSF is the most significant.For chest lesions,PSF is superior to TOF to the improve SUVmax,8.96% vs 5.26%(P <0.05),which is similar in superfacial lesions.Improvement of SULmax,SUVmean and SUVmax by PSF is better than that by TOF,which is 9.22% vs.1.22%,8.56% vs.1.78% and 9.33% vs.1.11%(P <0.05).But for pelvic lesions,TOF is superior to PSF to improve SULmax and SUVmax,which is 18.72% vs.12.29% and 20.69% vs.15.41%(P <0.05).For Abdominal lesions,there is no significant difference in Metabolic index increase between TOF and PSF(P>0.05).When BMI>25,improvement of SULmax and SUVmax by TOF is better than that by PSF,which is 10.45% vs.6.16% and 10.27% vs.6.43% respectively(P <0.05).But when Dmax≤2.0cm,PSF is significantly superior to TOF to improve SUVmax,which is 11.68% vs.4.78%(P<0.05).When BMI<25 and Dmax>2.0cm,no difference appeare between them.Conclusion:Both TOF and PSF can improve the metabolic parameter of malignant lesions and TOF+PSF is the most significant one.But as for chest and superfacial lesions,especially for smaller lesions,PSF is obviously better than TOF.On the contrary,for pelvic lesions,when BMI>25,TOF has more advantage.