Retrospective Analysis Of Risk Factors Of Sepsis-associated Liver Injury Of 91 Cases

Objective:To analyze the risk factors of sepsis-associated liver injury.Method:We did a retrospective study on clinical profiles in patients with sepsis from Intensive Care Unit(ICU)of First Affiliated Hospital of China Medical University between January 1st,2015 and December 31th,2016.According to whether the patient had sepsis-induced liver injury during ICU,the patients were divided into liver injury group(91 cases)and non-liver injury group(143 cases),and the two groups were compared with each other by statistical analysis.Result:Of 234 patients with sepsis,91(38.9%)developed sepsis-associated liver injury,which emerged at a mean time of(3.35±8.30)days after admission to ICU.The number of male patients in both groups was greater than the number of female patients.The age of onset of sepsis-associated liver injury group was(58.56±17.41)years,ICU time was(10±11.00)days,APACHEII score was(15.27±8.05),SOFA score was(7.62±3.75),and the age of non sepsis-associated liver injury group was(63.76±14.00).)years old,ICU time(5.36 ± 4.04)days,APACHE Ⅱ score(13.17 ±4.90),SOFA score(5.64 ± 3.24),the difference was statistically significant.There was a statistically significant difference in whether the two groups had surgery in the hospital,some of the primary sites of infection(abdomen,lungs,skin and soft tissue)and long-term drinking history.The results of binary logistic regression analysis showed that ICU duration(OR=1.082,95%CI 1.024,1.144,P=0.005)and MODS(OR=5.160,95%CI 2.689,9.918,P=0.000)were significant risk factors for sepsisassociated liver injury.The more organ dysfunction in septic MODS patients,the higher the incidence of liver injury.Conclusion:1.Patients with sepsis-associated liver injury are more common in elderly patients and male patients.2.The condition of patients with sepsis-associated liver injury is more serious than that of patients without liver injury.3.Prolonged stay in the ICU or combined with MODS is a risk factor for liver damage in patients with sepsis.4.With the increase of organ dysfunction in septic MODS patients,the incidence of epsis-associated liver injury increased.