| Feline panleukopenia is a highly infectious disease caused by the feline panleukopenia virus.The feline panleukopenia virus replicates in the bone marrow,and the destruction of bone marrow hematopoietic cells and severe inflammation in the intestine cause a significant reduction in white blood cells.The disease occurs mostly in young cats under 1 year of age and has a high morbidity and mortality rate.Although there have been many reports regarding the treatment of feline panleukopenia in the past,limited data are available on factors affecting the outcome,including living environment,transmission of infection,and vaccination status.Therefore,in this investigation,we analyzed the clinical symptoms of infected cats and the data of laboratory tests to identify indicators that can predict the outcome of the outcome.In this study,366 cases of confirmed feline distemper were collected from an animal hospital.The basic conditions and laboratory results of the cats were statistically analyzed to summarize the pathogenesis of feline distemper;50 surviving cases and 19 deceased cases with complete case preservation were selected and defined as the surviving and deceased groups,respectively,and their leukocyte levels,lymphocyte levels and neutrophil levels at the time of admission and 24 hours were analyzed to investigate the risk factors affecting the prognosis of feline distemper and their predictive value for the prognosis of feline distemper.To investigate the risk factors affecting the prognosis of feline distemper and their predictive value for the prognostic assessment of feline distemper in the clinical setting.The results of the survey on the incidence pattern of feline panleukopenia were as follows:between January 2022 and December 2022,there were 366 confirmed cases,with cats of all ages,with the highest number of cases(54.6%)in months 0 to March.Of the confirmed positive cases,46%were females and 54%were males.50%of the affected cats were obese,with the lowest incidence in obese cats,34.5%in ideal size and 11.7%in lean size.The incidence rate of unimmunized cats was 51.1%.The most common clinical symptoms were loss of appetite,depression,vomiting and diarrhea,accounting for 47%,45.4%,24%and 26.2%,respectively.Most of the affected cats had normal body temperature,but 21%still had elevated body temperature.The blood count showed that 66.3%of the cats had leukopenia,49.4%had neutropenia,and 42.2%had lymphopenia.37.7%had thrombocytopenia.Serum amyloid A protien(SAA)test results statistically showed that 63.1%of the affected cats were severely inflamed and 22.6%were mildly inflamed.Biochemical results showed that 47.8%of the cats had hyperglycemia,34.8%had hyperbilirubinemia,and 17.4%had elevated urea nitrogen.Blood gas test results showed metabolic acidosis in 47%of the cats.Of the 112 cats hospitalized,93 were cured and 19 died.The results of the study on the regression index of feline panleukopenia showed that the statistical analysis of the 69 cases in which the experiment was conducted showed that there were significant differences in body weight,immune status,mental status,white blood cell count,lymphocyte count,and neutrophil count between surviving and dead cats(P<0.05),and that the appetite,mental status,vomiting,white blood cell count,lymphocyte count,neutrophil count of the dead animals 24 hours after consultation were significantly different from those of the surviving animals(P<0.05).There was a extremely significant difference between the surviving animals(P<0.01).Logistic regression results associated with the regression of panleukopenia in cats showed that:Attendance and 24 hour leukocyte counts were positively associated with the regression of panleukopenia in cats(β>0,P<0.05),and the risk of death in cats with 24 hours vomiting was0.03 times higher than in cats without vomiting(P<0.05).Cox proportional risk regression analysis of factors influencing length of stay in surviving cats revealed that cats with higher leukocyte levels at presentation and at 24 hours of presentation had shorter length of stay(P<0.05).The ROC curve yielded that the leukocyte count was valuable in predicting the regression of panleukopenia in cats,and the 24 hours visit leukocyte count was more accurate for the regression of panleukopenia in cats,with an AUC=0.884 and an optimal threshold value of 1.25×10~9/L.This experiment summarized the pathogenesis of feline panleukopenia by investigating and counting 366 cases of feline panleukopenia.By comparing the clinical symptoms and blood indices of surviving and dead cats,it was found that cats with vomiting symptoms 24 hours after consultation had an increased risk of death,and the leukocyte count was positively correlated with regression.It can also provide effective guidance for the clinical diagnosis and prevention of feline panleukopenia. |
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